PMS2 wt Allele

Known as: PMS2 Postmeiotic Segregation Increased 2 (S. cerevisiae) wt Allele, Postmeiotic Segregation Increased, S. cerevisiae, 2 Gene, PMS2CL 
Human PMS2 wild-type allele is located in the vicinity of 7p22.2 and is approximately 36 kb in length. This allele, which encodes PMS1 protein… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2004-2014
012320042014

Papers overview

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2015
2015
Heterozygous deleterious mutation of the PMS2 gene is a cause of Lynch syndrome, an autosomal dominant cancer disease. However… (More)
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2014
2014
The presence of highly homologous pseudocopies can compromise the mutation analysis of a gene of interest. In particular, when… (More)
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2013
2013
Lynch syndrome is characterized by mutations in one of four mismatch repair genes, MLH1, MSH2, MSH6, or PMS2. Clinical mutation… (More)
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2012
2012
Heterozygous PMS2 germline mutations are associated with Lynch syndrome. Up to one third of these mutations are genomic deletions… (More)
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2011
2011
Lynch syndrome is characterized by mutations in the mismatch repair genes MLH1, MSH2, MSH6, and PMS2. In PMS2, detection of… (More)
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2010
2010
Germline mutation detection in PMS2, one of four mismatch repair genes associated with Lynch syndrome, is greatly complicated by… (More)
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2010
2010
Heterozygous mutations in PMS2 are involved in Lynch syndrome, whereas biallelic mutations are found in Constitutional mismatch… (More)
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2010
2010
Sequence exchange between PMS2 and its pseudogene PMS2CL, embedded in an inverted duplication on chromosome 7p22, has been… (More)
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2008
2008
Heterozygous germline mutations in one of the mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2 cause hereditary… (More)
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Highly Cited
2004
Highly Cited
2004
The MutLalpha heterodimer formed by mismatch repair (MMR) proteins MLH1 and PMS2 is a major component of the MMR complex, yet… (More)
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