PMS2 gene

Known as: PMS1 homolog 2, mismatch repair system component, HNPCC4, MLH4 
This gene is involved in mismatch repair and mutations in the gene result in hereditary non-polyposis colon cancer 4.

Topic mentions per year

Topic mentions per year

1995-2018
051019952018

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2007
2007
Since the first report by our group in 1999, more than 20 unrelated biallelic mutations in DNA mismatch repair genes (MMR) have… (More)
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2007
2007
Mutations of the PMS2 DNA repair gene predispose to a characteristic range of malignancies, with either childhood onset (when… (More)
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2006
2006
Mutations within the DNA mismatch repair gene, "postmeiotic segregation increased 2" (PMS2), have been associated with a… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND & AIMS Germline mutations in the DNA mismatch repair (MMR) genes MSH2, MSH6, or MLH1 predispose to colorectal cancer… (More)
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2005
2005
PURPOSE Most colorectal cancers that have high levels of microsatellite instability (MSI-H) show loss of immunohistochemical… (More)
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2004
2004
The MutLalpha heterodimer formed by mismatch repair (MMR) proteins MLH1 and PMS2 is a major component of the MMR complex, yet… (More)
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2000
2000
Turcot's syndrome is a genetic disease characterized by the concurrence of primary brain tumors and colon cancers and/or multiple… (More)
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1998
1998
Hereditary non-polyposis colorectal cancer (HNPCC) is a genetically heterogeneous disease for which PMS2 gene, a member of the… (More)
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1995
1995
The hPMS2 gene (HGMW-approved symbol PMS2) encodes a mutL homolog that causes hereditary non-polyposis colon cancer (HNPCC) when… (More)
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1995
1995
The PMS2 gene encodes a protein that is involved in DNA mismatch repair and is mutated in a subset of patients with hereditary… (More)
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