Skip to search formSkip to main contentSkip to account menu

PML/RARA Fusion Protein

Known as: PML-RAR Protein, Inducer of Acute Promyelocytic Leukemia, PML-RARalpha Fusion Protein 
A fusion protein (797 aa, ~106 kDa) that is encoded by the PML/RARA fusion gene. This protein contains the B-box and the RING-finger domain from… 
National Institutes of Health

Related topics

Related topics

4 relations
Fusion GenePML genePML/RARA Fusion Genearsenic trioxide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Recruitment of the Histone Methyltransferase SUV39H1 and Its Role in the Oncogenic Properties of the Leukemia-Associated PML-Retinoic Acid Receptor Fusion Protein
ABSTRACT Leukemia-associated fusion proteins establish aberrant transcriptional programs, which result in the block of… 
Highly Cited
2004
Highly Cited
2004
Personal exposure to ultrafine particles in the workplace: exploring sampling techniques and strategies.
Recently, toxicological and epidemiological studies on health effects related to particle exposure suggest that 'ultrafine… 
Highly Cited
2000
Highly Cited
2000
Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.
Highly Cited
1998
Highly Cited
1998
The Promyelocytic Leukemia Gene Product (PML) Forms Stable Complexes with the Retinoblastoma Protein
ABSTRACT PML is a nuclear protein with growth-suppressive properties originally identified in the context of the PML-retinoic… 
Highly Cited
1997
Highly Cited
1997
Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences.
Acute promyelocytic leukemia (APML) is characterized by abnormal myeloid development, resulting an accumulation of leukemic… 
Review
1997
Review
1997
Acute promyelocytic leukemia: biology and treatment.
The discovery of the specific PML-RAR alpha gene rearrangement in acute promyelocytic leukemia (APL) and of the in vitro and in… 
Highly Cited
1995
Highly Cited
1995
Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix- associated PML bodies
The PML protein was first identified as part of a fusion product with the retinoic acid receptor alpha (RAR alpha), resulting… 
Highly Cited
1995
Highly Cited
1995
The PML gene encodes a phosphoprotein associated with the nuclear matrix.
The t(15;17)(q22;q12) translocation is the cytogenetic hallmark of acute promyelocytic leukemia (APL). The PML and retinoic acid… 
Highly Cited
1994
Highly Cited
1994
The t(15;17) translocation alters a nuclear body in a retinoic acid‐reversible fashion.
Nuclear bodies (NBs) are ultrastructurally defined granules predominantly found in dividing cells. Here we show that PML, a… 
Highly Cited
1994
Highly Cited
1994
PML, a growth suppressor disrupted in acute promyelocytic leukemia
The nonrandom chromosomal translocation t(15;17)(q22;q21) in acute promyelocytic leukemia (APL) juxtaposes the genes for retinoic… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)