PML/RARA Fusion Protein

Known as: PML-RAR Protein, Inducer of Acute Promyelocytic Leukemia, PML-RARalpha Fusion Protein 
A fusion protein (797 aa, ~106 kDa) that is encoded by the PML/RARA fusion gene. This protein contains the B-box and the RING-finger domain from… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2017
05101519912017

Papers overview

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Highly Cited
2010
Highly Cited
2010
Many different molecular mechanisms have been associated with PML-RARalpha-dependent transformation of hematopoietic progenitors… (More)
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Highly Cited
2000
Highly Cited
2000
RAR and AML1 transcription factors are found in leukemias as fusion proteins with PML and ETO, respectively. Association of PML… (More)
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Highly Cited
1997
Highly Cited
1997
Acute promyelocytic leukemia (APML) is characterized by abnormal myeloid development, resulting an accumulation of leukemic… (More)
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Highly Cited
1997
Highly Cited
1997
The unique t(15;17) of acute promyelocytic leukemia (APL) fuses the PML gene with the retinoic acid receptor alpha (RAR alpha… (More)
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Highly Cited
1996
Highly Cited
1996
It has been shown recently in China that arsenic trioxide (As2O3) is a very effective treatment for acute promyelocytic leukemia… (More)
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Highly Cited
1996
Highly Cited
1996
From March 1993 to October 1993, 20 consecutive, newly diagnosed acute promyelocytic leukemia (APL) patients from 13 Italian… (More)
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1996
1996
All-trans retinoic acid (t-RA) administration leads to complete remission in acute promyelocytic leukemia (APL) patients by… (More)
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Highly Cited
1995
Highly Cited
1995
Many human leukemias are characterized by chromosomal translocations yielding hybrid RNAs capable of encoding fusion chimeric… (More)
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Highly Cited
1994
Highly Cited
1994
The nonrandom chromosomal translocation t(15;17)(q22;q21) in acute promyelocytic leukemia (APL) juxtaposes the genes for retinoic… (More)
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Highly Cited
1991
Highly Cited
1991
We have previously shown that the t(15;17) translocation specifically associated with acute promyelocytic leukemia (APL) fuses… (More)
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