PM 00104

Known as: PM-00104, PM00104 
A synthetic alkaloid compound, related to natural alkaloid compounds, found in molluscs (jorumycin) and sponges (renieramycins), with potential… (More)

Topic mentions per year

Topic mentions per year

2005-2016
02420052016

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
This study: (i) investigated the in vitro cytotoxicity and mode of action of lurbinectedin (PM01183) and Zalypsis® (PM00104… (More)
Is this relevant?
2013
2013
PM00104 (Zalypsis®) is a synthetic tetrahydroisoquinoline alkaloid with potent antiproliferative activity against tumor cell… (More)
  • table 1
  • table 2
  • table 3
  • table 4
  • table 5
Is this relevant?
2012
2012
Background:PM00104 binds guanines at DNA minor grooves, impacting DNA replication and transcription. A phase I study was… (More)
  • figure 1
  • table 1
  • table 2
  • table 3
  • table 4
Is this relevant?
2012
2012
BACKGROUND AND OBJECTIVE PM00104 (Zalypsis(®)) is a novel marine-derived compound that has shown antineoplastic activity against… (More)
Is this relevant?
2012
2012
PM00104 (Zalypsis®) is a new synthetic alkaloid with potent cytotoxic activity against tumor cell lines. This phase I clinical… (More)
Is this relevant?
2011
2011
The aim of this study was to characterize the population pharmacokinetics of PM00104 (Zalypsis®) in cancer patients. A total of… (More)
  • table 1
  • table 2
  • figure 1
  • table 3
  • figure 2
Is this relevant?
2009
2009
Zalypsis (PM00104) is a novel tetrahydroisoquinoline alkaloid related to trabectedin [ecteinascidin 743 (Et743)]. Et743 and… (More)
Is this relevant?
2009
2009
2568 Background: PM00104 is a novel synthetic alkaloid related to the marine compounds jorumycin and renieramycins. Preliminary… (More)
Is this relevant?
2008
2008
ET-743 (Yondelis®, trabectedin) and PM00104 (Zalypsis®) are marine derived compounds which demonstrate anti-tumor activity. The… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2005
2005
A rapid and sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) assay was developed and validated to quantify a… (More)
Is this relevant?