Zalypsis

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2006-2016
02420062016

Papers overview

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Review
2014
Review
2014
PM00104 (Zalypsis) is a synthethic tetrahydroisoquinolone alkaloid, which is structurally similar to many marine organisms. The… (More)
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2013
2013
This study: (i) investigated the in vitro cytotoxicity and mode of action of lurbinectedin (PM01183) and Zalypsis® (PM00104… (More)
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2013
2013
Zalypsis® is a marine compound in phase II clinical trials for multiple myeloma, cervical and endometrial cancer, and Ewing’s… (More)
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2012
2012
Background:PM00104 binds guanines at DNA minor grooves, impacting DNA replication and transcription. A phase I study was… (More)
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2011
2011
BACKGROUND Although the majority of patients with acute myeloid leukemia initially respond to conventional chemotherapy, relapse… (More)
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2011
2011
Trabectedin and Zalypsis are two potent anticancer tetrahydroisoquinoline alkaloids that can form a covalent bond with the amino… (More)
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2011
2011
The difference in melting temperature of a double-stranded (ds) DNA molecule in the absence and presence of bound ligands can… (More)
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2009
2009
Zalypsis is a new synthetic alkaloid tetrahydroisoquinoline antibiotic that has a reactive carbinolamine group. This… (More)
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2009
2009
Multiple myeloma (MM) remains incurable, and new drugs with novel mechanisms of action are still needed. In this report, we have… (More)
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2009
2009
Zalypsis (PM00104) is a novel tetrahydroisoquinoline alkaloid related to trabectedin [ecteinascidin 743 (Et743)]. Et743 and… (More)
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