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PLCG2 protein, human
Known as:
1-Phosphatidylinositol Phosphodiesterase
, 1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Gamma 2
, PLC-Gamma-2
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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (1265 aa, ~148 kDa) is encoded by the human PLCG2 gene. This protein plays a role…
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National Institutes of Health
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Related topics
Related topics
19 relations
1-Phosphatidylinositol phosphodiesterase
1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase
B Cell Receptor Signaling Pathway
ERBB Family Signaling Pathway
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Broader (1)
Phospholipase C gamma 2
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Peptidoglycan and lipopolysaccharide activate PLCγ2, leading to enhanced cytokine production in macrophages and dendritic cells
Daisuke Aki
,
Yasumasa Minoda
,
+9 authors
A. Yoshimura
Genes to Cells
2008
Corpus ID: 20231363
In macrophages and monocytes, microbial components trigger the production of pro‐inflammatory cytokine through Toll‐like…
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2008
2008
Vav/Phospholipase Cgamma2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis.
V. Cremasco
,
D. Graham
,
D. Novack
,
W. Swat
,
R. Faccio
Arthritis & Rheumatism
2008
Corpus ID: 5320653
OBJECTIVE Accumulating evidence indicates an important role of neutrophils in the development of rheumatoid arthritis (RA…
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Highly Cited
2004
Highly Cited
2004
Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites.
K. Suzuki-Inoue
,
J. Wilde
,
+5 authors
S. Watson
Biochemical Journal
2004
Corpus ID: 6566160
Glycoproteins GPVI and GPIb-IX-V stimulate robust tyrosine phosphorylation of Syk and PLCg2 (phospholipase Cg2) in washed…
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Highly Cited
2003
Highly Cited
2003
MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223).
S. Andreae
,
S. Buisson
,
F. Triebel
Blood
2003
Corpus ID: 14368276
On encountering a danger signal, dendritic cells (DCs) undergo a complex maturation process and become specialized in antigen…
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Highly Cited
2003
Highly Cited
2003
A critical role for phospholipase Cgamma2 in alphaIIbbeta3-mediated platelet spreading.
P. Wonerow
,
Andrew C Pearce
,
D. Vaux
,
S. Watson
Journal of Biological Chemistry
2003
Corpus ID: 28664287
The interaction of fibrinogen with the integrin alphaIIbbeta3 plays a crucial role in platelet adhesion and platelet activation…
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Highly Cited
2002
Highly Cited
2002
Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets.
P. Wonerow
,
A. Obergfell
,
+8 authors
S. Watson
Biochemical Journal
2002
Corpus ID: 1060598
The platelet collagen receptor glycoprotein VI (GPVI) and the fibrinogen receptor integrin alphaIIbbeta3 trigger intracellular…
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Highly Cited
2002
Highly Cited
2002
The small proteoglycan decorin supports adhesion and activation of human platelets.
G. Guidetti
,
A. Bertoni
,
M. Viola
,
Enrica Tira
,
C. Balduini
,
M. Torti
Blood
2002
Corpus ID: 8057699
Decorin is a small leucine-rich proteoglycan able to interact with several molecules of the subendothelial matrix, such as…
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Highly Cited
2002
Highly Cited
2002
Identification of radiation-specific responses from gene expression profile
W. Park
,
C. Hwang
,
+11 authors
Jeong-Sun Seo
Oncogene
2002
Corpus ID: 23907619
The responses to ionizing radiation (IR) in tumors are dependent on cellular context. We investigated radiation-related…
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Highly Cited
2000
Highly Cited
2000
A requirement for lipid rafts in B cell receptor induced Ca2+ flux
M. Aman
,
K. Ravichandran
Current Biology
2000
Corpus ID: 11511189
Highly Cited
2000
Highly Cited
2000
Interaction of Linker for Activation of T Cells with Multiple Adapter Proteins in Platelets Activated by the Glycoprotein VI-selective Ligand, Convulxin*
N. Asazuma
,
J. Wilde
,
+9 authors
Stephen P. Watson
Journal of Biological Chemistry
2000
Corpus ID: 9769712
The snake venom toxin convulxin activates platelets through the collagen receptor glycoprotein VI (GPVI)/Fc receptor γ-chain (FcR…
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