1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase

Known as: Phospholipase C, Phosphatidylinositide-4,5-Bisphosphate, 1 Phosphatidylinositol 4,5 Bisphosphate Phosphodiesterase, Phosphoinositide Phospholipase C [Chemical/Ingredient] 
A type C phospholipase with specificity towards PHOSPHATIDYLINOSITOLS that contain INOSITOL 1,4,5-TRISPHOSPHATE. Many of the enzymes listed under… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
BACKGROUND Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from… (More)
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Review
2012
Review
2012
The importance of the physiological function of phosphatase and tensin homologue (PTEN) is illustrated by its frequent disruption… (More)
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Review
2009
Review
2009
The phosphoinositide 3-kinase (PI3K) pathway is a key signal transduction system that links oncogenes and multiple receptor… (More)
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Review
2002
Review
2002
Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation… (More)
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Highly Cited
2002
Highly Cited
2002
The S/T-protein kinases activated by phosphoinositide 3-kinase (PI3K) regulate a myriad of cellular processes. Here, we show that… (More)
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Highly Cited
2000
Highly Cited
2000
Phosphoinositide 3-kinase (PI3K) activity is crucial for leukocyte function, but the roles of the four receptor-activated… (More)
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Highly Cited
1998
Highly Cited
1998
Phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) is a key molecule involved in cell growth signaling. We demonstrated… (More)
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Highly Cited
1997
Highly Cited
1997
A signaling pathway was delineated by which insulin-like growth factor 1 (IGF-1) promotes the survival of cerebellar neurons. IGF… (More)
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Highly Cited
1997
Highly Cited
1997
The regulation of the serine-threonine kinase Akt by lipid products of phosphoinositide 3-kinase (PI 3-kinase) was investigated… (More)
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1984
1984
The phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2] [and to a lesser extent, the phosphatidylinositol-4-phosphate (PtdIns4P… (More)
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