Identification of radiation-specific responses from gene expression profile

@article{Park2002IdentificationOR,
  title={Identification of radiation-specific responses from gene expression profile},
  author={Woong-Yang Park and Charles Hwang and Chang-Nim Im and Min-Ji Kang and Jeong Yong Woo and JohnY. Kim and Yon Su Kim and Ju-Han Kim and Ho Yeoul Kim and Kyung-A Kim and Hyung-Jin Yu and Sue-Jae Lee and Yun-Sil Lee and J W Seo},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={8521-8528}
}
The responses to ionizing radiation (IR) in tumors are dependent on cellular context. We investigated radiation-related expression patterns in Jurkat T cells with nonsense mutation in p53 using cDNA microarray. Expression of 2400 genes in γ-irradiated cells was distinct from other stimulations like anti-CD3, phetohemagglutinin (PHA) and concanavalin A (ConA) in unsupervised clustering analysis. Among them, 384 genes were selected for their IR-specific changes to make ‘RadChip’. In spite of p53… CONTINUE READING
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Biochem

WY Park, CI Hwang, +8 authors JS. Seo
Biophys. Res. Commun., 282, 934 – 939. • 2001
View 5 Excerpts
Highly Influenced

Proc

MB Eisen, PT Spellman, PO Brown, D. Botstein
Natl. Acad. Sci. USA,, 95, 14863 – 14868. • 1998
View 6 Excerpts
Highly Influenced

Mol

P Dent, DB Reardon, DK Morrison, TW. Sturgill
Cell. Biol., 15, 4125 – 4135. • 1995
View 4 Excerpts
Highly Influenced

Radiat

Z Fuks, A Haimovitz, D Hannahan, D Kufe, R. Weichselbaum
Oncol. Invest., 1, 81 – 93. • 1993
View 4 Excerpts
Highly Influenced

Free Radic

R Schreck, K Albermann, PA. Baeuerle
Res. Commun., 17, 221 – 237. • 1992
View 5 Excerpts
Highly Influenced

J

S Cemerski, A Cantagrel, JP Van Meerwijk, P. Romagnoli
Biol. Chem., 277, 19585 – 19593. • 2002
View 2 Excerpts

Comp

SA Amundson, M Bittner, P Meltzer, J Trent, AJ. Fornace
Biochem. Physiol. B. Biochem. Mol. Biol., 129, 703 – 710. • 2001
View 3 Excerpts

Nat

KK Khanna, Jackson SP.
Genet., 27, 247 – 254. • 2001
View 3 Excerpts

Nat

GM Wahl, Carr AM.
Cell. Biol., 3, E277 – E286. • 2001

Nat

J. Quackenbush
Rev. Genet., 2, 418 – 427. • 2001