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PLCG2 gene
Known as:
PHOSPHOLIPASE C, GAMMA-2
, Phospholipase C, Gamma 2 (Phosphatidylinositol-Specific) Gene
, PLCG2
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This gene is involved in the generation of second messengers in the transmembrane signaling of ligand-activated growth factor receptors.
National Institutes of Health
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Related topics
Related topics
10 relations
1-Phosphatidylinositol phosphodiesterase
1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase
Hydrolysis
PLCG2 protein, human
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Associations between rare microglia-linked Alzheimer's disease risk variants and subcortical brain volumes in young individuals
T. Lancaster
Alzheimer's & Dementia
2019
Corpus ID: 148574805
2017
2017
BTK C 481 S-Mediated Resistance to Ibrutinib in Chronic Lymphocytic Leukemia
J. Ruppert
,
D. Guinn
,
+28 authors
J. Byrd
2017
Corpus ID: 40610509
Purpose Therapeutic targeting of Bruton tyrosine kinase (BTK) with ibrutinib in chronic lymphocytic leukemia has led to a…
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2017
2017
A comparative global phosphoproteomics analysis of obinutuzumab (GA101) versus rituximab (RTX) against RTX sensitive and resistant Burkitt lymphoma (BL) demonstrates differential phosphorylation of…
A. Awasthi
,
D. Rolland
,
+9 authors
M. Cairo
OncoTarget
2017
Corpus ID: 12286955
We recently demonstrated that obinutuzumab (GA101), a novel glycoengineered type II CD20 Ab compared to rituximab (RTX) mediates…
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2017
2017
Membrane damage is at the core of Alzheimer's disease
J. Hardy
Lancet Neurology
2017
Corpus ID: 33730377
2017
2017
Molecular characterization and expression analysis of olive flounder (Paralichthys olivaceus) phospholipase C gamma 1 and gamma 2
S. Woo
,
H. Jo
,
H. Lee
,
Joon-Ki Chung
Fish and Shellfish Immunology
2017
Corpus ID: 1737550
2016
2016
the Development and Expansion of Resistant Subclones Precedes Relapse during Ibrutinib Therapy in Patients with CLL
J. Woyach
,
D. Guinn
,
+27 authors
A. Johnson
2016
Corpus ID: 208385302
The Bruton9s Tyrosine Kinase (BTK) inhibitor ibrutinib is very effective in chronic lymphocytic leukemia (CLL). Resistance in CLL…
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2015
2015
Gene expression profiling analysis of osteosarcoma cell lines
Lu Sun
,
J. Li
,
B. Yan
Molecular Medicine Reports
2015
Corpus ID: 8034466
Osteosarcoma (OS) is the most common type of primary bone malignancy and has a poor prognosis. To investigate the mechanisms of…
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2001
2001
Variations in the human phospholipase Cγ2 gene in patients with B-cell defects of unknown etiology
Demin Wang
,
E. C. Boylin
,
+4 authors
M. Conley
Immunogenetics
2001
Corpus ID: 30647685
Abstract. Our recent studies using targeted gene disruption have shown that defects in phospholipase Cγ2 (PLCγ2) result in a B…
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1995
1995
Phospholipase C gamma-2 (Plcg2) and phospholipase C gamma-1 (Plcg1) map to distinct regions in the human and mouse genomes.
A. C. Argeson
,
T. Druck
,
+4 authors
L. Siracusa
Genomics
1995
Corpus ID: 41013555
The phospholipase C gamma-2 (Plcg2) gene encodes an enzyme that plays a crucial role in intracellular signal transduction…
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1994
1994
Mapping the gene that encodes phosphatidylinositol-specific phospholipase C-gamma 2 in the human and the mouse.
Diana Hernandez
,
Sean E. Egan
,
I. Yulug
,
Elizabeth M.C. Fisher
Genomics
1994
Corpus ID: 28018338
We have mapped the PLCG2 gene, which encodes the enzyme phosphatidyl inositol-specific phospholipase C-gamma 2. This is one of…
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