PLCG2 protein, human

Known as: 1-Phosphatidylinositol Phosphodiesterase, 1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Gamma 2, PLC-Gamma-2 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (1265 aa, ~148 kDa) is encoded by the human PLCG2 gene. This protein plays a role… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2018
051019892018

Papers overview

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Highly Cited
2012
Highly Cited
2012
Whole-exome sequencing was performed in a family affected by dominantly inherited inflammatory disease characterized by recurrent… (More)
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Highly Cited
2008
Highly Cited
2008
Immunoreceptor tyrosine-based activation motif (ITAM)-containing proteins have recently been demonstrated in macrophages and… (More)
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2008
2008
In macrophages and monocytes, microbial components trigger the production of pro-inflammatory cytokine through Toll-like… (More)
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Highly Cited
2007
Highly Cited
2007
Control of integrin-mediated adhesion and migration by chemokines plays a critical role in B cell development, differentiation… (More)
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Highly Cited
2005
Highly Cited
2005
The clinical course of chronic lymphocytic leukemia (CLL) differs significantly between patients with mutated (M-CLL) and… (More)
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2004
2004
Tyrosine phosphorylation of phospholipase Cgamma2 (PLCgamma2) is a crucial activation switch that initiates and maintains… (More)
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Highly Cited
2003
Highly Cited
2003
The interaction of fibrinogen with the integrin alphaIIbbeta3 plays a crucial role in platelet adhesion and platelet activation… (More)
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2002
2002
The platelet collagen receptor glycoprotein VI (GPVI) and the fibrinogen receptor integrin alphaIIbbeta3 trigger intracellular… (More)
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2000
2000
Although the major biochemical events triggered by ligation of the B-cell receptor (BCR) have been well defined [1] [2], little… (More)
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1996
1996
Although there are multiple potential collagen-binding proteins on platelets, the contribution of each to collagen-induced… (More)
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