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PLCG2 protein, human

Known as: 1-Phosphatidylinositol Phosphodiesterase, 1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Gamma 2, PLC-Gamma-2 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (1265 aa, ~148 kDa) is encoded by the human PLCG2 gene. This protein plays a role… 
National Institutes of Health

Related topics

Related topics

19 relations
1-Phosphatidylinositol phosphodiesterase1-Phosphatidylinositol-4,5-bisphosphate phosphodiesteraseB Cell Receptor Signaling PathwayERBB Family Signaling Pathway

Broader (1)

Phospholipase C gamma 2

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Ca2+ Regulation of Trypanosoma brucei Phosphoinositide Phospholipase C
ABSTRACT We characterized a phosphoinositide phospholipase C (PI-PLC) from the procyclic form (PCF) of Trypanosoma brucei. The… 
2014
2014
Silencing of phosphoinositide-specific phospholipase C ε remodulates the expression of the phosphoinositide signal transduction pathway in human osteosarcoma cell lines.
BACKGROUND Ezrin, a member of the ezrin-radixin-moesin family, is involved in the metastatic spread of osteosarcoma. Ezrin binds… 
2012
2012
BTK Inhibition Targets in Vivo CLL Proliferation Through Its Effects On B-Cell Receptor Signaling Activity.
Abstract 2903 Purpose: Bruton tyrosine kinase (BTK) is a component of the B-cell receptor signaling pathway. Ibrutinib… 
2007
2007
A role for PLCgamma2 in platelet activation by homocysteine.
The aim of this study was to examine the homocysteine effect on phospholipase Cgamma2 (PLCgamma2) activation and to investigate… 
Highly Cited
2002
Highly Cited
2002
The small proteoglycan decorin supports adhesion and activation of human platelets.
Decorin is a small leucine-rich proteoglycan able to interact with several molecules of the subendothelial matrix, such as… 
2002
2002
Alboluxin, a Snake C-type Lectin from Trimeresurus albolabris Venom is a Potent Platelet Agonist acting via GPIb and GPVI
Summary Alboluxin, a potent platelet activator, was purified from Trimeresurus albolabris venom with a mass of 120 kDa non… 
2002
2002
Tyrosine phosphatase CD45 regulates hydrogen peroxide-induced calcium mobilization in B cells.
By taking advantage of established CD45-deficient DT40 cells, the roles of CD45 in oxidative stress signaling were investigated… 
2001
2001
Phosphatidylinositol 3-kinase-dependent translocation of phospholipase Cgamma2 in mouse megakaryocytes is independent of Bruton tyrosine kinase translocation.
Activation of the collagen receptor glycoprotein VI (GPVI) by a collagen-related peptide (CRP) induces stimulation of platelets… 
1996
1996
Cloning and functional analysis of the hematopoietic cell-specific phospholipase C(gamma)2 promoter.
Phospholipase C(gamma)2 (PLCgamma2) is a phospholipid-converting enzyme which, upon receptor stimulation, is activated within… 
1994
1994
Ethanol-induced alteration in activities of cerebral phosphatidylinositol 4,5-biphosphate-specific and cytosolic phospholipase C in the brain: analysis using NG 108-15 cells and brains from ethanol…
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