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PLCG2 protein, human

Known as: 1-Phosphatidylinositol Phosphodiesterase, 1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Gamma 2, PLC-Gamma-2 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (1265 aa, ~148 kDa) is encoded by the human PLCG2 gene. This protein plays a role… 
National Institutes of Health

Related topics

Related topics

19 relations
1-Phosphatidylinositol phosphodiesterase1-Phosphatidylinositol-4,5-bisphosphate phosphodiesteraseB Cell Receptor Signaling PathwayERBB Family Signaling Pathway

Broader (1)

Phospholipase C gamma 2

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Peptidoglycan and lipopolysaccharide activate PLCγ2, leading to enhanced cytokine production in macrophages and dendritic cells
In macrophages and monocytes, microbial components trigger the production of pro‐inflammatory cytokine through Toll‐like… 
2008
2008
Vav/Phospholipase Cgamma2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis.
OBJECTIVE Accumulating evidence indicates an important role of neutrophils in the development of rheumatoid arthritis (RA… 
Highly Cited
2007
Highly Cited
2007
Diverging signaling events control the pathway of GPVI down-regulation in vivo.
Coronary artery thrombosis is often initiated by platelet activation on collagen-rich subendothelial layers in the disrupted… 
Highly Cited
2003
Highly Cited
2003
MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223).
On encountering a danger signal, dendritic cells (DCs) undergo a complex maturation process and become specialized in antigen… 
Highly Cited
2003
Highly Cited
2003
A critical role for phospholipase Cgamma2 in alphaIIbbeta3-mediated platelet spreading.
The interaction of fibrinogen with the integrin alphaIIbbeta3 plays a crucial role in platelet adhesion and platelet activation… 
Highly Cited
2002
Highly Cited
2002
Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets.
The platelet collagen receptor glycoprotein VI (GPVI) and the fibrinogen receptor integrin alphaIIbbeta3 trigger intracellular… 
Highly Cited
2002
Highly Cited
2002
Identification of radiation-specific responses from gene expression profile
The responses to ionizing radiation (IR) in tumors are dependent on cellular context. We investigated radiation-related… 
Highly Cited
2002
Highly Cited
2002
The small proteoglycan decorin supports adhesion and activation of human platelets.
Decorin is a small leucine-rich proteoglycan able to interact with several molecules of the subendothelial matrix, such as… 
Highly Cited
2000
Highly Cited
2000
A requirement for lipid rafts in B cell receptor induced Ca2+ flux
Highly Cited
2000
Highly Cited
2000
Interaction of Linker for Activation of T Cells with Multiple Adapter Proteins in Platelets Activated by the Glycoprotein VI-selective Ligand, Convulxin*
The snake venom toxin convulxin activates platelets through the collagen receptor glycoprotein VI (GPVI)/Fc receptor γ-chain (FcR… 
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