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PLCG2 protein, human

Known as: 1-Phosphatidylinositol Phosphodiesterase, 1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Gamma 2, PLC-Gamma-2 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (1265 aa, ~148 kDa) is encoded by the human PLCG2 gene. This protein plays a role… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND Mendelian analysis of disorders of immune regulation can provide insight into molecular pathways associated with host… Expand
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Highly Cited
2009
Highly Cited
2009
The lymphatic vasculature originates from the blood vasculature through a mechanism relying on Prox1 expression and VEGFC… Expand
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2007
2007
Coronary artery thrombosis is often initiated by platelet activation on collagen-rich subendothelial layers in the disrupted… Expand
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Highly Cited
2005
Highly Cited
2005
The clinical course of chronic lymphocytic leukemia (CLL) differs significantly between patients with mutated (M-CLL) and… Expand
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Highly Cited
2003
Highly Cited
2003
On encountering a danger signal, dendritic cells (DCs) undergo a complex maturation process and become specialized in antigen… Expand
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2003
2003
The interaction of fibrinogen with the integrin alphaIIbbeta3 plays a crucial role in platelet adhesion and platelet activation… Expand
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2002
2002
Decorin is a small leucine-rich proteoglycan able to interact with several molecules of the subendothelial matrix, such as… Expand
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2002
2002
Phospholipase Cgamma2 (PLCgamma2) plays a critical role in the functions of the B cell receptor in B cells and of the FcRgamma… Expand
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Highly Cited
2000
Highly Cited
2000
Although the major biochemical events triggered by ligation of the B-cell receptor (BCR) have been well defined [1] [2], little… Expand
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2000
2000
To determine the role of amino acids in the second and third intracellular (IC) loops of the Ca2+-sensing receptor (CaR) in… Expand
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