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PKSI 527

Known as: PKSI-527 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

PhenylalanineTranexamic Acid
analogs & derivatives

Papers overview

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2005
2005
Synergistic antithrombotic effect of a combination of NO donor and plasma kallikrein inhibitor.
2001
2001
Binding diversity of a noncovalent-type low-molecular-weight serine protease inhibitor and function of a catalytic water molecule: X-ray crystal structure of PKSI-527--inhibited trypsin.
PKSI-527 is a noncovalent-type low-molecular-weight inhibitor. The X-ray crystal structure of the trypsin-PKSI-527 complex… 
2001
2001
Isolation of plasma kallikrein by high efficiency affinity chromatography and its characterization.
We established a simple method for the purification of human plasma kallikrein (PK) by affinity chromatography and characterized… 
1999
1999
Amino acids and peptides. LIII. Synthesis and biological activities of some pseudo-peptide analogs of PKSI-527, a plasma kallikrein selective inhibitor: the importance of the peptide backbone.
Pseudo-peptide analogs of trans-4-aminomethylcyclohexanecarbonyl-L-phenylalanyl-4-aminopheny l acetic acid (PKSI-527, plasma… 
1998
1998
Design of plasma kallikrein inhibitors: functional and structural requirements of plasma kallikrein inhibitors.
The synthetic plasma kallikrein (PK) inhibitor trans-4-aminomethylcyclohexanecarbonylphenylalanine-4-carboxyme thylanilide (PKSI… 
1996
1996
Effects of a highly selective synthetic inhibitor of plasma kallikrein on disseminated intravascular coagulation in rats.
1993
1993
Effects of a highly selective plasma kallikrein inhibitor on collagen-induced arthritis in mice
A study was conducted to evaluate the effects of a new, highly selective plasma kallikrein inhibitor, PKSI-527, on collagen… 
1992
1992
Development of plasma kallikrein selective inhibitors.
During the course of the development of active center-directed plasmin inhibitors, it was found that N-(trans-4… 
1992
1992
A finding of highly selective synthetic inhibitor of plasma kallikrein; its action to bradykinin generation, intrinsic coagulation and experimental DIC.
We found a novel and highly selective synthetic inhibitor of plasma kallikrein (PK), called PKSI-527; the Ki value was 0.81… 
1990
1990
Effect of a highly selective plasma-kallikrein synthetic inhibitor on contact activation relating to kinin generation, coagulation and fibrinolysis.
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