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Tranexamic Acid

Known as: trans-4-(Aminomethyl)cyclohexanecarboxylic Acid, Tranexamic Acid [Chemical/Ingredient], Acidum tranexamicum 
A synthetic derivative of the amino acid lysine with antifibrinolytic activity. With strong affinity for the five lysine-binding sites of plasminogen… Expand
National Institutes of Health

Related topics

Related topics

29 relations
10 ML Tranexamic Acid 100 MG/ML Injection [Cyklokapron]Blood Coagulation DisordersBlood Coagulation FactorDecreased Fibrinolysis [PE]
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Narrower (11)

AmchafibrinAnvitoffCyklokapronExacyl
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Broader (1)

Antifibrinolytic Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study.
OBJECTIVES To characterize contemporary use of tranexamic acid (TXA) in combat injury and to assess the effect of its… Expand
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Highly Cited
2011
Highly Cited
2011
The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.
BACKGROUND The aim of the CRASH-2 trial was to assess the effects of early administration of tranexamic acid on death, vascular… Expand
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Highly Cited
2010
Highly Cited
2010
Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2) A randomised, placebo-controlled trial.
BACKGROUND Tranexamic acid can reduce bleeding in patients undergoing elective surgery. We assessed the effects of early… Expand
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Highly Cited
2010
Highly Cited
2010
Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial.
BACKGROUND Topical application of tranexamic acid to bleeding wound surfaces reduces blood loss in patients undergoing some major… Expand
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Highly Cited
2010
Highly Cited
2010
Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial.
BACKGROUND Tranexamic acid can reduce bleeding in patients undergoing elective surgery. We assessed the effects of early… Expand
Is this relevant?
Highly Cited
2008
Highly Cited
2008
A comparison of aprotinin and lysine analogues in high-risk cardiac surgery.
BACKGROUND Antifibrinolytic agents are commonly used during cardiac surgery to minimize bleeding and to reduce exposure to blood… Expand
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Highly Cited
2004
Highly Cited
2004
The pharmacology and management of the vitamin K antagonists: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.
This article concerning the pharmacokinetics and pharmacodynamics of vitamin K antagonists (VKAs) is part of the Seventh American… Expand
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Highly Cited
2003
Highly Cited
2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
BACKGROUND Total knee arthroplasty (TKA) is often carried out using a tourniquet and shed blood is collected in drains… Expand
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Highly Cited
1999
Highly Cited
1999
Alexa Dyes, a Series of New Fluorescent Dyes that Yield Exceptionally Bright, Photostable Conjugates
Alexa 350, Alexa 430, Alexa 488, Alexa 532, Alexa 546, Alexa 568, and Alexa 594 dyes are a new series of fluorescent dyes with… Expand
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Highly Cited
1996
Highly Cited
1996
Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients.
We investigated the effect of a fibrinolytic inhibitor, tranexamic acid, on blood loss and blood transfusion in knee arthroplasty… Expand
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