FAQ

Tranexamic Acid

Known as: trans-4-(Aminomethyl)cyclohexanecarboxylic Acid, Tranexamic Acid [Chemical/Ingredient], Acidum tranexamicum 
A synthetic derivative of the amino acid lysine with antifibrinolytic activity. With strong affinity for the five lysine-binding sites of plasminogen… (More)

Topic mentions per year

Topic mentions per year

1964-2018
010020030019642018

Related topics

Related topics

25 relations

Narrower (11)

AmchafibrinAnvitoffCyklokapronExacyl
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Broader (1)

Antifibrinolytic Agents
Blood Coagulation DisordersBlood Coagulation FactorDecreased Fibrinolysis [PE]In Blood
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Tranexamic Acid
Thrombosis
agonists
Blood Coagulation Disorders
Subarachnoid Hemorrhage
Blood Coagulation Factor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
HALT-IT - tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial
BACKGROUND Gastrointestinal bleeding is a common emergency that causes substantial mortality worldwide. Acute upper and lower… (More)
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Highly Cited
2012
Highly Cited
2012
Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study.
OBJECTIVES To characterize contemporary use of tranexamic acid (TXA) in combat injury and to assess the effect of its… (More)
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Highly Cited
2011
Highly Cited
2011
The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.
BACKGROUND The aim of the CRASH-2 trial was to assess the effects of early administration of tranexamic acid on death, vascular… (More)
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Highly Cited
2010
Highly Cited
2010
Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial.
BACKGROUND Tranexamic acid can reduce bleeding in patients undergoing elective surgery. We assessed the effects of early… (More)
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Highly Cited
2010
Highly Cited
2010
Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial.
BACKGROUND Topical application of tranexamic acid to bleeding wound surfaces reduces blood loss in patients undergoing some major… (More)
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Highly Cited
2003
Highly Cited
2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
BACKGROUND Total knee arthroplasty (TKA) is often carried out using a tourniquet and shed blood is collected in drains… (More)
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2002
2002
Pharmacokinetics of tranexamic acid during cardiopulmonary bypass.
BACKGROUND Tranexamic acid (TA) reduces blood loss and blood transfusion during heart surgery with cardiopulmonary bypass (CPB… (More)
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Highly Cited
2000
Highly Cited
2000
Tranexamic acid reduces blood loss in total hip replacement surgery.
UNLABELLED Intraoperatively administered, tranexamic acid (TA) does not reduce bleeding in total hip replacement (THR). Therefore… (More)
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Highly Cited
1996
Highly Cited
1996
Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients.
We investigated the effect of a fibrinolytic inhibitor, tranexamic acid, on blood loss and blood transfusion in knee arthroplasty… (More)
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Highly Cited
1995
Highly Cited
1995
The dose-response relationship of tranexamic acid.
BACKGROUND Prophylactic administration of the antifibrinolytic drug tranexamic acid decreases bleeding and transfusions after… (More)
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