Tranexamic Acid

Known as: trans-4-(Aminomethyl)cyclohexanecarboxylic Acid, Tranexamic Acid [Chemical/Ingredient], Acidum tranexamicum 
A synthetic derivative of the amino acid lysine with antifibrinolytic activity. With strong affinity for the five lysine-binding sites of plasminogen… (More)

Topic mentions per year

Topic mentions per year

1964-2018
010020030019642018

Papers overview

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Review
2014
Review
2014
BACKGROUND Gastrointestinal bleeding is a common emergency that causes substantial mortality worldwide. Acute upper and lower… (More)
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Highly Cited
2012
Highly Cited
2012
OBJECTIVES To characterize contemporary use of tranexamic acid (TXA) in combat injury and to assess the effect of its… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND The aim of the CRASH-2 trial was to assess the effects of early administration of tranexamic acid on death, vascular… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Tranexamic acid can reduce bleeding in patients undergoing elective surgery. We assessed the effects of early… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Topical application of tranexamic acid to bleeding wound surfaces reduces blood loss in patients undergoing some major… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Total knee arthroplasty (TKA) is often carried out using a tourniquet and shed blood is collected in drains… (More)
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2002
2002
BACKGROUND Tranexamic acid (TA) reduces blood loss and blood transfusion during heart surgery with cardiopulmonary bypass (CPB… (More)
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Highly Cited
2000
Highly Cited
2000
UNLABELLED Intraoperatively administered, tranexamic acid (TA) does not reduce bleeding in total hip replacement (THR). Therefore… (More)
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Highly Cited
1996
Highly Cited
1996
We investigated the effect of a fibrinolytic inhibitor, tranexamic acid, on blood loss and blood transfusion in knee arthroplasty… (More)
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Highly Cited
1995
Highly Cited
1995
BACKGROUND Prophylactic administration of the antifibrinolytic drug tranexamic acid decreases bleeding and transfusions after… (More)
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