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Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice.
TLDR
Monocyte chemoattractant protein-1 plays a unique and crucial role in the initiation of atherosclerosis and may provide a new therapeutic target in this disorder. Expand
Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes.
TLDR
Results support a particular role for the myeloperoxidase-expressing macrophages in atheroma complication and the acute coronary syndromes and identify granulocytemacrophage colony-stimulating factor as an endogenous regulator of macrophage myelopersidase expression in human atherosclerosis. Expand
Matrix metalloproteinase-9 (92 kDa gelatinase/type IV collagenase) from U937 monoblastoid cells: correlation with cellular invasion.
TLDR
Invasion was significantly inhibited by EDTA, alpha 2-macroglobulin and tissue inhibitor of metalloproteinases-1, but not by inhibitors of cathepsin G and leukocyte elastase, and good correlations between invasiveness, type IV collagenolysis and proMMP-9 production were shown. Expand
ApoE knockout mice expressing human matrix metalloproteinase-1 in macrophages have less advanced atherosclerosis.
TLDR
The data suggest that remodeling of the neointimal extracellular matrix by MMP-1 is beneficial in the progression of lesions, and the transgenic mice demonstrated decreased lesion size compared with control littermates. Expand
Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization.
TLDR
A mechanism by which lipid lowering may stabilize vulnerable plaques by reduced expression and activity of enzymes that degrade the arterial extracellular matrix is established and render atheroma less susceptible to disruption and thrombosis by favoring collagen accumulation in the fibrous cap. Expand
Focal cellular origin and regulation of interstitial collagenase (matrix metalloproteinase-1) are related to menstrual breakdown in the human endometrium.
TLDR
MMP-1 is focally expressed in stromal cells of the functional layer of the endometrium, when and where steroid receptors disappear, and especially where tissue breakdown is prominent, which point to an essential role for M MP-1 in the early stages of menstruation. Expand
Development of plasma kallikrein selective inhibitors.
TLDR
The plasma kallikrein selective inhibitor, N-(trans- 4-aminomethylcyclohexanecarbonyl)-phenylalanine-4-carboxy methyl- anilide (Tra-Phe-APAA) was designed and synthesized and a new affinity gel (PKSI-Toyopearl) was synthesized for the rapid purification of plasma k allikre in from human plasma. Expand
Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis.
TLDR
Mechanistically, the studies reveal that PRCP(gt/gt) aortas express reduced levels of Kruppel-like factors 2 and 4, thrombomodulin, and eNOS mRNA, suggesting endothelial cell dysfunction, and PRCP siRNA treatment of endothelial cells shows increased ROS and uncoupled eNos and decreased protein C activation because of throm bommodulin inactivation. Expand
Effect of a highly selective plasma-kallikrein synthetic inhibitor on contact activation relating to kinin generation, coagulation and fibrinolysis.
TLDR
The results indicate that PKSI-527 shows great potential in elucidating the significance of PK, and as such deserves further investigation. Expand
Synthesis of stereoisomeric analogues of endomorphin-2, H-Tyr-Pro-Phe-Phe-NH(2), and examination of their opioid receptor binding activities and solution conformation.
TLDR
The data clearly indicated that the three dimensional structure of endomorphin-2 with the natural l-configuration was the most suitable for binding within the mu receptor, but specific residues are important for activity. Expand
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