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PITRM1 gene

Known as: PreP peptidasome, PreP, KIAA1104 
National Institutes of Health

Related topics

Related topics

1 relation
Metalloproteases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids
Mutations in pitrilysin metallopeptidase 1 (PITRM1), a mitochondrial protease involved in mitochondrial precursor processing and… 
2018
2018
Mitochondrial PITRM1 peptidase loss-of-function in childhood cerebellar atrophy
Objective To identify the genetic basis of a childhood-onset syndrome of variable severity characterised by progressive… 
2018
2018
Functional requirement for human pitrilysin metallopeptidase 1 arginine 183, mutated in amyloidogenic neuropathy
Here we report the enzymologic characterization of recombinant human pitrilysin metallopeptidase 1 (Pitrm1) and derivative… 
2015
2015
Synergistic effect of fluoride and sodium hexametaphosphate in toothpaste on enamel demineralization in situ.
Review
2015
Review
2015
Defective PITRM 1 mitochondrial peptidase is associated with A amyloidotic neurodegeneration
Reviewer 1 is critical of the mouse studies and is not convinced of their actual relevance and is especially critical of the… 
2015
2015
Perturbation of cellular proteostasis networks identifies pathways that modulate precursor and intermediate but not mature levels of frataxin
Friedreich’s Ataxia is a genetic disease caused by expansion of an intronic trinucleotide repeat in the frataxin (FXN) gene… 
2015
2015
Autotransfusion of Hemothorax Blood Is Prothrombotic but Inhibits Platelet Aggregation: A Potentiator of Disseminated Intravascular Coagulation
Introduction Hemostatic resuscitation in combat casualty care presents unique challenges not typically encountered in… 
2010
2010
Genetic and biochemical studies of SNPs of the mitochondrial Aβ-degrading protease, hPreP
2009
2009
The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors
Pitrm1 is a zinc metalloendopeptidase that has been implicated in Alzheimer's disease and mitochondrial peptide degradation, but… 
1999
1999
Cloning, expression, and characterization of human metalloprotease 1: a novel member of the pitrilysin family of metalloendoproteases.
A novel cDNA, designated human metalloendoprotease 1 (hMP1), was identified on the basis of homology to known… 
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