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c-Myc Suppresses p21WAF1/CIP1 Expression during Estrogen Signaling and Antiestrogen Resistance in Human Breast Cancer Cells*
Estrogen rapidly induces expression of the proto-oncogene c-myc. c-Myc is required for estrogen-stimulated proliferation of breast cancer cells, and deregulated c-Myc expression has been implicated… Expand
Hsp90/p50cdc37 Is Required for Mixed-lineage Kinase (MLK) 3 Signaling*
Mixed-lineage kinase 3 (MLK3) is a mitogen-activated protein kinase (MAPK) kinase kinase that activates MAPK pathways, including the c-Jun NH2-terminal kinase (JNK) and p38 pathways. MLK3 and its… Expand
Evidence for transcriptional and post-transcriptional control of the cellular thymidine kinase gene.
We have studied the cell cycle-regulated expression of the thymidine kinase (TK) gene in mammalian tissue culture cells. TK mRNA and enzyme levels are low in resting, G0-phase cells, but increase… Expand
Antiestrogen ICI 182,780 decreases proliferation of insulin-like growth factor I (IGF-I)-treated MCF-7 cells without inhibiting IGF-I signaling.
Previous studies have suggested that antiestrogens inhibit MCF-7 cell proliferation by alteringthe expression or activity of components of the insulin-like growth factor I (IGF-I) signaling pathway,… Expand
Induction of cellular thymidine kinase occurs at the mRNA level.
- P. Stuart, M. Ito, C. J. Stewart, S. Conrad
- Biology, Medicine
- Molecular and cellular biology
- 1 June 1985
The thymidine kinase (TK) gene has been isolated from human genomic DNA. The gene was passaged twice by transfection of LTK- cells with human chromosomal DNA, and genomic libraries were made in… Expand
Independent regulation of thymidine kinase mRNA and enzyme levels in serum-stimulated cells.
We have studied the regulation of thymidine kinase mRNA and protein/enzyme expression in quiescent and serum-stimulated rat cells transfected with a human TK cDNA clone expressed from a number of… Expand
Role of plasmid-coded RNA and ribonuclease III in plasmid DNA replication
An in vitro replication system has been used to study the control of DNA replication of the relaxed plasmids Col E1 and RSF1030. An RNA transcript approximately 100 nucleotides long is synthesized… Expand
Estrogen increases brain expression of the mRNA encoding transthyretin, an amyloid beta scavenger protein.
Estrogen replacement therapy in postmenopausal women is associated with a reduced risk of Alzheimer's Disease (AD). The multiple mechanisms by which estrogen protects against AD are still unknown. To… Expand
Estrogen and progesterone are critical regulators of Stat5a expression in the mouse mammary gland.
Signal transducer and activator of transcription (Stat)5a is a well-established regulator of mammary gland development. Several pathways for activating Stat5a have been identified, but little is… Expand
Reversal of an antiestrogen-mediated cell cycle arrest of MCF-7 cells by viral tumor antigens requires the retinoblastoma protein-binding domain
Proliferation of MCF-7 cells is estrogen dependent and antiestrogen sensitive. In the absence of estrogens or presence of antiestrogens MCF-7 cells arrest in the G1 phase of the cell cycle, and this… Expand