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PINX1 gene

Known as: PIN2/TERF1 interacting, telomerase inhibitor 1, LPTS, MGC8850 
This gene plays a role in both chromosome segregation and telomerase regulation.
National Institutes of Health

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Related topics

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Chromosome SegregationInhibition of Cell ProliferationMitotic Metaphase

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PINX1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Association between the PINX1 and NAT2 polymorphisms and serum lipid levels
Jing nationality is a relatively conservative and isolated minority in China. Little is known about the association of the PIN2… 
2015
2015
PinX1 is up-regulated and associated with poor patients' survival in gliomas.
PinX1, a conserved nuclear protein, could maintain telomere integrity and plays an important role in regulating telomerase… 
Review
2015
Review
2015
LPTS: A Novel Tumor Suppressor Gene and a Promising Drug Target for Cancer Intervention.
Liver-related putative tumor suppressor (lpts) is a liver-related tumor suppressor candidate gene initially isolated by… 
2014
2014
PinX 1 without the G-patch motif suppresses proliferation , induces senescence , but does not inhibit telomerase activity in colorectal cancer SW 480 cells
Evidence suggests that Pin2/TRF1-interacting protein X1 (PinX1) inhibits telomerase activity in many types of cancer cells. G… 
2009
2009
PinX1 is recruited to the mitotic chromosome periphery by Nucleolin and facilitates chromosome congression.
2006
2006
Expression of telomerase inhibitor Pinx1 in leukemia cells and its correlation with telomerase activity
AIM: To study the expression of telomerase inhibitor Pinx1 in acute leukemia cells and during the differentiation of acute… 
2004
2004
Molecular analysis of PinX1 in medulloblastomas
Our group has previously demonstrated a high frequency of allelic loss on the short arm of chromosome 8 and identified a region… 
2004
2004
Human PinX1, a potent telomerase inhibitor, is not involved in human gastrointestinal tract carcinoma.
PinX1 was isolated as a Pin2/TRF1 binding protein that also binds to the telomerase catalytic subunit hTERT. The gene is a potent… 
2003
2003
Mutation analysis of novel human liver-related putative tumor suppressor gene in hepatocellular carcinoma.
AIM To find the point mutations meaningful for inactivation of liver-related putative tumor suppressor gene (LPTS) gene, a human… 
2002
2002
[The cloning and expression of a novel mouse gene mLPTS and its subcellular localization].
A novel mouse gene mLPTS was cloned by EST assembling, RT-PCR and DNA sequencing. The gene fragment for mLPTS is 1244 bp in… 
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