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PIK3CB wt Allele

Known as: P110BETA, PI3K, p110-Beta 
Human PIK3CB wild-type allele is located in the vicinity of 3q22.3 and is approximately 105 kb in length. This allele, which encodes… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Therapeutic inhibitors are being developed against the phosphoinositide 3-kinase (PI3K) pathway, the deregulation of which drives… Expand
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2010
2010
PI3Ks (phosphoinositide 3-kinases) play a critical role in platelet functional responses. PI3Ks are activated upon P2Y12 receptor… Expand
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Highly Cited
2009
Highly Cited
2009
Several phosphoinositide 3-kinase (PI3K) catalytic subunit inhibitors are currently in clinical trial. We therefore sought to… Expand
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Highly Cited
2009
Highly Cited
2009
Phosphatidylinositol 3-kinase (PI3K) isoforms PI3Kbeta and PI3Kgamma are implicated in platelet adhesion, activation, and… Expand
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2009
2009
The PI3K family is thought to participate in TLR signaling, and it has been reported to be a negative regulator of TLR-mediated… Expand
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Highly Cited
2008
Highly Cited
2008
The p110 isoforms of phosphoinositide 3-kinase (PI3K) are acutely regulated by extracellular stimuli. The class IA PI3K catalytic… Expand
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Highly Cited
2007
Highly Cited
2007
Recent genetic knock-in and pharmacological approaches have suggested that, of class IA PI3Ks (phosphatidylinositol 3-kinases… Expand
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Highly Cited
2006
Highly Cited
2006
Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug targets, but the unique roles of PI3-K isoforms… Expand
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Highly Cited
2006
Highly Cited
2006
Class I phosphoinositide 3-kinase contains four isoforms of the catalytic subunit, p110alpha, -beta, -gamma, and -delta. At… Expand
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Highly Cited
2005
Highly Cited
2005
The PIK3CA gene encoding the p110alpha subunit of Class IA phosphatidylinositol 3-kinases (PI3Ks) is frequently mutated in human… Expand
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