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PIK3CB wt Allele

Known as: P110BETA, PI3K, p110-Beta 
Human PIK3CB wild-type allele is located in the vicinity of 3q22.3 and is approximately 105 kb in length. This allele, which encodes… 
National Institutes of Health

Related topics

Related topics

15 relations
3q22.3ApoptosisB Cell Receptor Signaling PathwayERBB Family Signaling Pathway

Broader (1)

PIK3CB gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Abstract B008: Design and development of a novel series of PI3K-p110beta/delta-selective inhibitors with combined tumor immunotherapeutic, growth inhibition, and anti-metastatic activity
The phosphatidylinositide 3-kinases (PI3Ks) have emerged as important therapeutic targets for the treatment of solid and… 
2015
2015
Water Network Determines Selectivity for a Series of Pyrimidone Indoline Amide PI3KBeta Inhibitors over PI3K-Delta
2015
2015
Abstract 4696: Combining AZD8186, an inhibitor of PI3Kbeta, with inhibitors of PI3Kalpha and mTORC1/2 gives comprehensive pathway suppression and enhanced antitumor activity in PTEN null tumors
2013
2013
Role of class IA PI 3-kinase isoforms in neointima formation following balloon angioplasty: only p110alpha is important
Growth factor induced proliferation and migration of vascular smooth muscle cells (SMCs) are essential for neointima formation… 
2010
2010
Discovery of phosphatidylinositol 3-kinase inhibitory compounds from the Screening Committee of Anticancer Drugs (SCADS) library.
Identification of new uses for existing drugs is known to be an efficient approach in drug discovery. The identification of a… 
2004
2004
Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells.
Phosphoinositide 3-kinase (PI 3-kinase) activity is required for growth factor-induced cytoskeletal regulation and cell migration… 
2003
2003
Distinct phosphoinositide 3-kinases mediate mast cell degranulation in response to G-protein-coupled versus FcepsilonRI receptors.
Phosphoinositide (PI) 3-kinases are critical regulators of mast cell degranulation. The Class IA PI 3-kinases p85/p110beta and… 
Review
2002
Review
2002
Phosphoinositide 3-kinases in lysophosphatidic acid signaling: regulation and cross-talk with the Ras/mitogen-activated protein kinase pathway.
Highly Cited
2000
Highly Cited
2000
Specific Requirement for the p85-p110α Phosphatidylinositol 3-Kinase during Epidermal Growth Factor-stimulated Actin Nucleation in Breast Cancer Cells*
We have studied the role of phosphatidylinositol 3-kinases (PI 3-kinases) in the regulation of the actin cytoskeleton in MTLn3… 
Review
2000
Review
2000
Structure and function of phosphatidylinositol-3,4 kinase.
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