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Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
TLDR
The demonstration that ATX and lysoPLD are identical suggests that autocrine or paracrine production of LPA contributes to tumor cell motility, survival, and proliferation, and provides potential novel targets for therapy of pathophysiological states including cancer.
Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
TLDR
The results suggest that the constitutive activation of 41-/43-kDa MAP kinases in tumor cells is not due to the disorder of MAP kinase themselves, but is due toThe disorder of Raf-1, Ras, or some other signaling molecules upstream of Ras.
Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor.
TLDR
ZSTK474 is a new PI3K inhibitor with strong antitumor activity against human cancer xenografts without toxic effects in critical organs and merits further investigation as an anticancer drug.
Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).
TLDR
WWP1 thus negatively regulates TGF-beta signaling in cooperation with Smad7, and WWP1 failed to ubiquitinate R-Smads and SnoN, suggesting unique pathophysiological roles of WWP 1 and Smurfs.
Significant correlation of monocyte chemoattractant protein‐1 expression with neovascularization and progression of breast carcinoma
TLDR
Tumor‐associated macrophages are known to play a crucial role in tumor progression and MCP‐1 is one of the major chemokines capable of inducing chemotactic migration of monocytes.
A human IAP-family gene, apollon, expressed in human brain cancer cells.
TLDR
It is suggested that Apollon protects SNB-78 cells from undergoing apoptosis and, at least in part, plays a role in tumorigenesis and drug resistance of this cell line.
ZSTK474 is an ATP‐competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms
TLDR
In vitro homogenous time‐resolved fluorescence kinase assay results indicate that ZSTK474 is an ATP‐competitive pan‐class I PI3K inhibitor.
Effect on tumor cells of blocking survival response to glucose deprivation.
TLDR
The UPR-inhibitory action of VST was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells.
Autotaxin Is Overexpressed in Glioblastoma Multiforme and Contributes to Cell Motility of Glioblastoma by Converting Lysophosphatidylcholine TO Lysophosphatidic Acid*
TLDR
The results suggest that the autocrine production of LPA by cancer cell-derived ATX and exogenously supplied LPC contribute to the invasiveness of cancer cells and that LPA1, ATX, and LPC-producing enzymes are potential targets for cancer therapy, including GBM.
Expression, Function, and Clinical Implications of the Estrogen Receptor β in Human Lung Cancers
TLDR
It is concluded that ERβ, but not ERα, is present in lung tissues with an important physiological function in normal lung and may play a role in growth and development of adenocarcinomas.
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