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PIK3CB gene

Known as: PIK3CB, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta, PI3K-BETA 
This gene is involved in apoptosis, cell growth and angiogenesis.
National Institutes of Health

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PIK3CB wt Allele
Phosphoinositide-3-Kinase, Catalytic, Beta PolypeptidePhosphorylationSignal Transduction

Papers overview

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2020
2020
N6-methyladenosine mRNA methylation of PIK3CB regulates AKT signalling to promote PTEN-deficient pancreatic cancer progression
Objective Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. Thus far, most drugs have failed… 
2019
2019
PI3K/AKT/β-Catenin Signaling Regulates Vestigial-Like 1 Which Predicts Poor Prognosis and Enhances Malignant Phenotype in Gastric Cancer
Although gastric cancer is a common cause of cancer mortality worldwide, its biological heterogeneity limits the available… 
Highly Cited
2018
Highly Cited
2018
PI3K Positively Regulates YAP and TAZ in Mammary Tumorigenesis Through Multiple Signaling Pathways
Breast cancer is a leading cause of death in women worldwide. Active mutations of PI3K catalytic subunit PIK3CA (e.g., H1047R… 
2018
2018
PIK3CB/p110&bgr; is a selective survival factor for glioblastoma
Background Glioblastoma (GBM) is difficult to treat. Phosphoinositide 3-kinase (PI3K) is an attractive therapeutic target for GBM… 
2017
2017
Functional characterization of a novel somatic oncogenic mutation of PIK3CB
Class I phosphoinositide 3-kinase (PI3K) enzymes have attracted considerable attention as drug targets in cancer therapy over the… 
Highly Cited
2012
Highly Cited
2012
SnapShot: Mammalian Rab Proteins in Endocytic Trafficking
Highly Cited
2009
Highly Cited
2009
PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer.
Several phosphoinositide 3-kinase (PI3K) catalytic subunit inhibitors are currently in clinical trial. We therefore sought to… 
2007
2007
Targeted RNA interference of phosphatidylinositol 3‐kinase p110‐β induces apoptosis and proliferation arrest in endometrial carcinoma cells
Phosphatidylinositol 3‐kinase (PI3K) signalling plays a pivotal role in intracellular signal transduction pathways involved in… 
Highly Cited
2006
Highly Cited
2006
Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus
Mutation of PIK3CA, the gene coding for the p110α catalytic subunit of phosphoinositide 3‐kinase (PI3K), has been reported in a… 
Highly Cited
2004
Highly Cited
2004
Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways
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