PHA 665752

Known as: PHA-665752, PHA665752 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2003-2017
05101520032017

Papers overview

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Highly Cited
2013
Highly Cited
2013
PURPOSE Although cetuximab, an anti-EGF receptor (EGFR) monoclonal antibody, is an effective treatment for patients with KRAS… (More)
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Highly Cited
2012
Highly Cited
2012
HER2 amplification is found in more than 15% of gastric cancers and is associated with poor clinical outcome. Lapatinib, a dual… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Ionizing radiation (IR) is effectively used in cancer therapy. However, in subsets of patients, a few radioresistant… (More)
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Highly Cited
2011
Highly Cited
2011
UNLABELLED c-Met, a high-affinity receptor for hepatocyte growth factor (HGF), plays a critical role in cancer growth, invasion… (More)
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Highly Cited
2011
Highly Cited
2011
Because of the critical roles of aberrant signaling in cancer, both c-MET and ALK receptor tyrosine kinases are attractive… (More)
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Highly Cited
2011
Highly Cited
2011
Therapies targeting receptor tyrosine kinases have shown efficacy in molecularly defined subsets of cancers. Unfortunately… (More)
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2008
2008
The c-Met receptor tyrosine kinase has been implicated in cellular transformation induced by mutant Ras, a commonly activated… (More)
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Highly Cited
2006
Highly Cited
2006
The success of molecular targeted therapy in cancer may depend on the selection of appropriate tumor types whose survival depends… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE c-MET is believed to be an attractive receptor target for molecular therapeutic inhibition. TPR-MET, a constitutively… (More)
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Highly Cited
2003
Highly Cited
2003
The c-Met receptor tyrosine kinase and its ligand, hepatocyte growth factor (HGF), have been implicated in the development and… (More)
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