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PHA 665752

Known as: PHA-665752, PHA665752 
National Institutes of Health

Papers overview

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2019
2019
A hepatocyte growth factor/MET-induced antiapoptotic pathway protects against radiation-induced salivary gland dysfunction.
2018
2018
Effects of PHA-665752 and vemurafenib combination treatment on in vitro and murine xenograft growth of human colorectal cancer cells with BRAFV600E mutations.
It remains unknown whether blockade of B-Raf proto-oncogene, serine/threonine kinase (BRAF)V600E signaling and MET proto-oncogene… 
2016
2016
c-MET inhibition enhances the response of the colorectal cancer cells to irradiation in vitro and in vivo.
The aim of the present study was to investigate the effect of hepatocyte growth factor receptor (c-MET) inhibition on the… 
2015
2015
Overexpression of PI3K p110α contributes to acquired resistance to MET inhibitor, in MET-amplified SNU-5 gastric xenografts
Gastric cancer is one of the most virulent malignant diseases and is the second leading cause of cancer mortality in the world… 
2013
2013
Oncogenic variant RON160 expression in breast cancer and its potential as a therapeutic target by small molecule tyrosine kinase inhibitor.
Aberrant expression of the RON receptor tyrosine kinase contributes to breast cancer malignancy. Although clinical trials of RON… 
2013
2013
Excessive MET signaling causes acquired resistance and addiction to MET inhibitors in the MKN45 gastric cancer cell line
SummaryThe clinical efficacy of MET tyrosine kinase inhibitors (MET-TKIs) is hindered by the emergence of acquired resistance… 
2013
2013
Knockdown of RON receptor kinase delays but does not prevent tumor progression while enhancing HGF/MET signaling in pancreatic cancer cell lines
In this study, the role of RON (receptor originated from nantes) in tumor progression was further investigated in context with… 
2011
2011
Antitumor Activity of SNX-2112, a Synthetic Heat Shock Protein-90 Inhibitor, in MET-Amplified Tumor Cells with or without Resistance to Selective MET Inhibition
Purpose: Heat shock protein-90 (HSP-90), a molecular chaperone required by numerous oncogenic kinases [e.g., HER-2, epidermal… 
2005
2005
Characterization, expression and function of c-Met in canine spontaneous cancers.
Aberrant expression of the proto-oncogene c-Met has been noted in a variety of human cancers. To better define the potential role… 
2005
2005
Inhibition of c-Met as a therapeutic strategy for esophageal adenocarcinoma.
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