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PHA 665752

Known as: PHA-665752, PHA665752 
 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Purpose: Although cetuximab, an anti-EGF receptor (EGFR) monoclonal antibody, is an effective treatment for patients with KRAS… Expand
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Highly Cited
2012
Highly Cited
2012
HER2 amplification is found in more than 15% of gastric cancers and is associated with poor clinical outcome. Lapatinib, a dual… Expand
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Highly Cited
2011
Highly Cited
2011
Because of the critical roles of aberrant signaling in cancer, both c-MET and ALK receptor tyrosine kinases are attractive… Expand
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Highly Cited
2011
Highly Cited
2011
UNLABELLED c-Met, a high-affinity receptor for hepatocyte growth factor (HGF), plays a critical role in cancer growth, invasion… Expand
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Review
2010
Review
2010
The MET tyrosine kinase signaling pathway is upregulated in many cancers, including lung cancer. The pathway normally promotes… Expand
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Highly Cited
2009
Highly Cited
2009
Aberrant proteins encoded from genes altered in tumors drive cancer development and may also be therapeutic targets. Here we… Expand
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Highly Cited
2007
Highly Cited
2007
Specific chromosomal translocations encoding chimeric transcription factors are considered to play crucial oncogenic roles in a… Expand
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Highly Cited
2006
Highly Cited
2006
The success of molecular targeted therapy in cancer may depend on the selection of appropriate tumor types whose survival depends… Expand
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Highly Cited
2005
Highly Cited
2005
Purpose: c-MET is believed to be an attractive receptor target for molecular therapeutic inhibition. TPR-MET, a constitutively… Expand
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Highly Cited
2003
Highly Cited
2003
The c-Met receptor tyrosine kinase and its ligand, hepatocyte growth factor (HGF), have been implicated in the development and… Expand
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