Characterization of STAT3 activation and expression in canine and human osteosarcoma
Investigation of the potential role of STAT3 in canine and human OSA and the biologic activity of a novel small molecule STAT3 inhibitor suggest that STAT3 activation contributes to the survival and proliferation of human and canine OSA cells, thereby providing a potentially promising target for therapeutic intervention.
A 12-year retrospective study of canine testicular tumors.
- A. Liao, P. Chu, Lih‐Sen Yeh, Chung-Tien Lin, Chen-Hsuan Liu
- MedicineJournal of Veterinary Medical Science
- 1 July 2009
It is indicated that cryptorchidism alone or in addition to age will significantly affect the incidence and type of canine testicular tumors, and a high detection rate of testicular tumor in Maltese dogs is documented for the first time.
Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors.
3 indolinones (SU11652, SU11654, and SU11655) are effective RTK inhibitors capable of disrupting the function of all forms of mutant Kit and may be useful in the treatment of spontaneous cancers expressing Kit mutations.
Chemotherapy-induced neutropenia is associated with prolonged remission duration and survival time in canine lymphoma.
Kynurenine 3-Monooxygenase (KMO), and Signal Transducer and Activator of Transcription 3 (STAT3) Expression is involved in Tumor Proliferation and Predicts Poor Survival in Canine Melanoma.
Investigation of expressions of KMO and STAT3/phosphorylated (pSTAT3) by immunohistochemical analysis in 85 cases of canine melanoma showed their expression levels were high within highly-mitotic melanoma cells, and KMO Overexpression was significantly associated with increased STAT3 and pSTAT3 expressions.
KIT gene exon 11 mutations in canine malignant melanoma.
Evaluation of dysregulation of the receptor tyrosine kinases Kit, Flt3, and Met in histiocytic sarcomas of dogs.
- R. Zavodovskaya, A. Liao, C. London
- Biology, MedicineAmerican Journal of Veterinary Research
- 31 March 2006
It is suggested that dysregulation of Kit/SCF, Flt3/Flt3L, and Met/HGF signaling pathways is unlikely to occur in histiocytic sarcomas of dogs and that inhibitors of the Kit, FlT3, and met pathways are unlikely to provide clinical benefit to dogs with histiocytes.
Gene-expression profiling to identify genes related to spontaneous tumor regression in a canine cancer model.
BACTERIAL ISOLATION AND ANTIBIOTIC SELECTION AFTER OVARIOHYSTERECTOMY OF CANINE PYOMETRA: A RETROSPECTIVE STUDY OF 55 CASES
The results of this study provide reliable information to choose an effective antibiotic before surgical intervention, especially for critical patients who cannot wait for the sensitivity test.