PF-4708671
National Institutes of Health
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Abstract Platelet activation and thrombus formation is a delicate process involving a series of crosstalk between different…
Inflammatory processes have been shown to be involved in development and progression of neurodegenerative diseases. Mammalian…
LTB4 is an inflammatory lipid mediator mainly biosynthesized by leukocytes. Since its implication in inflammatory diseases is…
The mechanistic target of rapamycin (mTOR) is a highly conserved and ubiquitously expressed kinase, which consists of two…
Hematopoietic stem cells (HSCs) are able to self-renew and to differentiate into all blood cells. HSCs reside in a low-perfusion…
AMP‐activated protein kinase (AMPK) is activated under conditions that deplete cellular ATP levels and elevate AMP levels. We…
Breast cancer is the second-leading cause of oncology-related death in US women. Of all invasive breast cancers, patients with…
Agents targeting insulin-like growth factor 1 receptor (IGF-1R) are being actively examined in clinical trials. Although there…
Pretzel Syndrome (also Polyhydramnios, Megalencephaly, and Symptomatic Epilepsy syndrome; PMSE) is a recently described rare…