Characterizing A Signaling Network That Maintains Hematopoietic Stem Cells

@inproceedings{NguyenMcCarty2017CharacterizingAS,
  title={Characterizing A Signaling Network That Maintains Hematopoietic Stem Cells},
  author={Michelle Nguyen-McCarty},
  year={2017}
}
Hematopoietic stem cells (HSCs) are able to self-renew and to differentiate into all blood cells. HSCs reside in a low-perfusion niche and depend on local signals to survive and to maintain the capacity for self-renewal. HSCs removed from the niche can survive if they receive hematopoietic cytokines, but they then lose the ability to self-renew. However, we showed previously that simultaneous inhibition of glycogen synthase kinase-3 (GSK-3) and mammalian target of rapamycin complex 1 (mTORC1… CONTINUE READING

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