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PF 04457845

Known as: PF-04457845, PF04457845 
 
National Institutes of Health

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2019
2019
BACKGROUND Cannabis is one of the most widely used drugs worldwide. Cannabis use disorder is characterised by recurrent use of… Expand
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2017
2017
A recent phase 1 trial of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10-2474 led to the death of one volunteer and… Expand
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2015
2015
Positron emission tomography with [11C]CURB was recently developed to quantify fatty acid amide hydrolase (FAAH), the enzyme… Expand
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2013
2013
INTRODUCTION Fatty acid amide hydrolase (FAAH) has a significant role in regulating endocannabinoid signaling in the central… Expand
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Highly Cited
2012
Highly Cited
2012
The effect of PF-04457845, a potent and selective fatty acid amide hydrolase-1 (FAAH1) inhibitor, on pain due to osteoarthritis… Expand
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2012
2012
UNLABELLED AIMS To evaluate the pharmacology and tolerability of PF-04457845, an orally available fatty acid amide hydrolase-1… Expand
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2012
2012
Fatty-acid amide hydrolase (FAAH) catalyzes the intracellular hydrolysis of the endocannabinoid anandamide and other bioactive… Expand
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Highly Cited
2011
Highly Cited
2011
The endogenous cannabinoid (endocannabinoid) anandamide is principally degraded by the integral membrane enzyme fatty acid amide… Expand
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2011
2011
Fatty acid amide hydrolase (FAAH) is an integral membrane serine hydrolase that degrades the fatty acid amide family of signaling… Expand
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2011
2011
Pfizer Worldwide Research and Development, Groton, CT 06340, USA (K.A., Y.Z., C.S., D.S.J.); Ann Arbor, MI 48105, USA (K.A., S.E… Expand
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