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PF 04457845

Known as: PF-04457845, PF04457845 
 
National Institutes of Health

Papers overview

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2019
2019
Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a…
BACKGROUND Cannabis is one of the most widely used drugs worldwide. Cannabis use disorder is characterised by recurrent use of… Expand
Highly Cited
2017
Highly Cited
2017
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
A clue to a drug's neurotoxicity? The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a… Expand
2015
2015
Blocking of Fatty Acid Amide Hydrolase Activity with PF-04457845 in Human Brain: A Positron Emission Tomography Study with the Novel Radioligand [11C]CURB
Positron emission tomography with [11C]CURB was recently developed to quantify fatty acid amide hydrolase (FAAH), the enzyme… Expand
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2015
2015
Deficits in spontaneous burrowing behavior in the rat bilateral monosodium iodoacetate model of osteoarthritis: an objective measure of pain-related behavior and analgesic efficacy.
OBJECTIVE To characterize deficits in burrowing behavior - an ethologically-relevant rodent behavior - in the monosodium… Expand
2013
2013
Synthesis and preclinical evaluation of [11C-carbonyl]PF-04457845 for neuroimaging of fatty acid amide hydrolase.
INTRODUCTION Fatty acid amide hydrolase (FAAH) has a significant role in regulating endocannabinoid signaling in the central… Expand
Highly Cited
2012
Highly Cited
2012
An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective…
Summary A randomised, placebo‐controlled clinical trial with PF‐04457845, a novel irreversible fatty acid amide hydrolase‐1… Expand
Highly Cited
2012
Highly Cited
2012
Assessment of the pharmacology and tolerability of PF-04457845, an irreversible inhibitor of fatty acid amide hydrolase-1, in healthy subjects.
UNLABELLED AIMS To evaluate the pharmacology and tolerability of PF-04457845, an orally available fatty acid amide hydrolase-1… Expand
Highly Cited
2012
Highly Cited
2012
Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.
Fatty-acid amide hydrolase (FAAH) catalyzes the intracellular hydrolysis of the endocannabinoid anandamide and other bioactive… Expand
Highly Cited
2011
Highly Cited
2011
Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.
Fatty acid amide hydrolase (FAAH) is an integral membrane serine hydrolase that degrades the fatty acid amide family of signaling… Expand
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Highly Cited
2011
Highly Cited
2011
Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain
The endogenous cannabinoid (endocannabinoid) anandamide is principally degraded by the integral membrane enzyme fatty acid amide… Expand
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