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PF 04457845

Known as: PF-04457845, PF04457845 
National Institutes of Health

Papers overview

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Highly Cited
2020
Highly Cited
2020
Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial
Highly Cited
2017
Highly Cited
2017
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
A clue to a drug's neurotoxicity? The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a… 
Highly Cited
2016
Highly Cited
2016
Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling
2015
2015
Deficits in spontaneous burrowing behavior in the rat bilateral monosodium iodoacetate model of osteoarthritis: an objective measure of pain-related behavior and analgesic efficacy.
Highly Cited
2012
Highly Cited
2012
Assessment of the pharmacology and tolerability of PF-04457845, an irreversible inhibitor of fatty acid amide hydrolase-1, in healthy subjects.
UNLABELLED AIMS To evaluate the pharmacology and tolerability of PF-04457845, an orally available fatty acid amide hydrolase-1… 
Highly Cited
2012
Highly Cited
2012
An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective…
Highly Cited
2012
Highly Cited
2012
Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.
2012
2012
Inhibitors of endocannabinoid breakdown for pain: Not so FA(AH)cile, after all
Highly Cited
2011
Highly Cited
2011
Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.
Fatty acid amide hydrolase (FAAH) is an integral membrane serine hydrolase that degrades the fatty acid amide family of signaling… 
Highly Cited
2011
Highly Cited
2011
Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain
The endogenous cannabinoid (endocannabinoid) anandamide is principally degraded by the integral membrane enzyme fatty acid amide… 
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