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PF 04457845

Known as: PF-04457845, PF04457845 
 
National Institutes of Health

Papers overview

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2019
2019
BACKGROUND Cannabis is one of the most widely used drugs worldwide. Cannabis use disorder is characterised by recurrent use of… Expand
Highly Cited
2017
Highly Cited
2017
A clue to a drug's neurotoxicity? The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a… Expand
2015
2015
Positron emission tomography with [11C]CURB was recently developed to quantify fatty acid amide hydrolase (FAAH), the enzyme… Expand
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2015
2015
OBJECTIVE To characterize deficits in burrowing behavior - an ethologically-relevant rodent behavior - in the monosodium… Expand
2013
2013
INTRODUCTION Fatty acid amide hydrolase (FAAH) has a significant role in regulating endocannabinoid signaling in the central… Expand
Highly Cited
2012
Highly Cited
2012
Summary A randomised, placebo‐controlled clinical trial with PF‐04457845, a novel irreversible fatty acid amide hydrolase‐1… Expand
Highly Cited
2012
Highly Cited
2012
UNLABELLED AIMS To evaluate the pharmacology and tolerability of PF-04457845, an orally available fatty acid amide hydrolase-1… Expand
Highly Cited
2012
Highly Cited
2012
Fatty-acid amide hydrolase (FAAH) catalyzes the intracellular hydrolysis of the endocannabinoid anandamide and other bioactive… Expand
Highly Cited
2011
Highly Cited
2011
Fatty acid amide hydrolase (FAAH) is an integral membrane serine hydrolase that degrades the fatty acid amide family of signaling… Expand
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Highly Cited
2011
Highly Cited
2011
The endogenous cannabinoid (endocannabinoid) anandamide is principally degraded by the integral membrane enzyme fatty acid amide… Expand
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