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PF 04457845

Known as: PF-04457845, PF04457845 
National Institutes of Health

Papers overview

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2017
2017
Genetic biomarker trumps tissue type in landmark oncology approval
2017
2017
Biotech R&D spending continues to rise
Review
2017
Review
2017
Smoke gets in your tics
Many (though not all) of my patients who have tried marijuana have felt that their tics improved after using it. Such self… 
2015
2015
Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats
Manipulations of the endocannabinoid system could potentially produce therapeutic effects with minimal risk of adverse cannabis… 
2014
2014
A Systems Pharmacology Perspective on the Clinical Development of Fatty Acid Amide Hydrolase Inhibitors for Pain
The level of the endocannabinoid anandamide is controlled by fatty acid amide hydrolase (FAAH). In 2011, PF‐04457845, an… 
2014
2014
The FAAH inhibitor PF‐04457845 has THC‐like rewarding and reinstatement effects in squirrel monkeys and increases dopamine levels in the nucleus accumbens shell in rats (838.6)
FAAH inhibitors (like URB597), that increase brain levels of anandamide, OEA and PEA, show promise for treatment of several… 
2014
2014
Conference on ‘ PUFA mediators : implications for human health ’ Symposium 3 : Cannabinoids in human health Elevating endocannabinoid levels : pharmacological strategies and potential therapeutic…
The endocannabinoid system consists of cannabinoid CB1 and CB2 receptors, of endogenous agonists for these receptors known as… 
2012
2012
Evaluation of a small library of carbamates and ureas, including PF-04457845, as potential imaging agents for fatty acid amide hydrolase (FAAH)
Evaluation of a small library of carbamates and ureas, including PF-04457845, as potential imaging agents for fatty acid amide… 
2012
2012
Nabilone in inflammatory pain: to be or not to be
Cannabis-like compounds have recently emerged as a target for novel pharmacotherapies aimed at ameliorating acute, inflammatory… 
2011
2011
Promising FAAH inhibitor moves into clinical trials.
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