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PF 04457845

Known as: PF-04457845, PF04457845 
National Institutes of Health

Papers overview

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2017
2017
Inhibition of Endocannabinoid-Metabolizing Enzymes in Peripheral Tissues Following Developmental Chlorpyrifos Exposure in Rats
Repeated developmental exposure to the organophosphate (OP) insecticide chlorpyrifos (CPF) inhibits brain fatty acid amide… 
2017
2017
Genetic biomarker trumps tissue type in landmark oncology approval
2017
2017
Biotech R&D spending continues to rise
2017
2017
Finding fault with Bial's fatal FAAH inhibitor
To understand whether the off-target activity profile of BIA 10-2474 was to blame, researchers used an activity-based proteomic… 
2016
2016
Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats
RationaleManipulations of the endocannabinoid system could potentially produce therapeutic effects with minimal risk of adverse… 
2014
2014
A Systems Pharmacology Perspective on the Clinical Development of Fatty Acid Amide Hydrolase Inhibitors for Pain
The level of the endocannabinoid anandamide is controlled by fatty acid amide hydrolase (FAAH). In 2011, PF‐04457845, an… 
2014
2014
The FAAH inhibitor PF‐04457845 has THC‐like rewarding and reinstatement effects in squirrel monkeys and increases dopamine levels in the nucleus accumbens shell in rats (838.6)
FAAH inhibitors (like URB597), that increase brain levels of anandamide, OEA and PEA, show promise for treatment of several… 
Highly Cited
2012
Highly Cited
2012
Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.
2012
2012
The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH).
2012
2012
Evaluation of a small library of carbamates and ureas, including PF-04457845, as potential imaging agents for fatty acid amide hydrolase (FAAH)
Evaluation of a small library of carbamates and ureas, including PF-04457845, as potential imaging agents for fatty acid amide… 
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