• Publications
  • Influence
Palmitoylation of huntingtin by HIP14is essential for its trafficking and function
TLDR
It is suggested that the expansion of the polyglutamine tract in htt results in decreased palmitoylation, which contributes to the formation of inclusion bodies and enhanced neuronal toxicity.
Presynaptic Trafficking of Synaptotagmin I Is Regulated by Protein Palmitoylation*
TLDR
It is concluded that palmitoylation is involved in trafficking of specific elements involved in transmitter release and that distinct mechanisms regulate addition and removal of palmitate on select neuronal proteins.
New drugs cost US$2.6 billion to develop
  • Asher Mullard
  • Medicine
    Nature Reviews Drug Discovery
  • 1 December 2014
TLDR
Olaparib is in Phase III trials for breast cancer and in Phase II trials for non-small-cell lung cancer, prostate cancer and colorectal cancer and four other PARP inhibitor candidates are in hot pursuit.
Maturing antibody–drug conjugate pipeline hits 30
TLDR
The text has been updated to clarify Stuart Lutzker's affiliation and the PDB has been corrected to PBD.
Parsing clinical success rates
  • Asher Mullard
  • Medicine, Biology
    Nature Reviews Drug Discovery
  • 30 June 2016
TLDR
The overall analysis lumped new molecular entities (NMEs; including small molecules Parsing clinical success rates) into single therapeutic areas, finding that rare disease drugs for non-cancer indications out-performed the average and projects that included biomarkers fared similarly well.
Protein–protein interaction inhibitors get into the groove
TLDR
Drug developers are getting closer to tapping an unmined gold reserve of protein–protein interaction targets, according to research published in the journal Science Advances.
Maturing antibody–drug conjugate pipeline hits 30
  • Asher Mullard
  • Biology, Chemistry
    Nature Reviews Drug Discovery
  • 30 April 2013
Driven by recent clinical breakthroughs and technological progress, 30 antibody–drug conjugates against over 24 targets are now in trials for blood cancers and solid tumours.
2012 FDA drug approvals
  • Asher Mullard
  • Medicine
    Nature Reviews Drug Discovery
  • 1 February 2013
Sting of Alzheimer's failures offset by upcoming prevention trials
  • Asher Mullard
  • Psychology, Biology
    Nature Reviews Drug Discovery
  • 31 August 2012
Three prevention trials in asymptomatic Alzheimer's disease patients will attempt to validate the amyloid hypothesis, evaluate biomarkers and set the stage for drug approvals.
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