• Publications
  • Influence
The molecular logic of endocannabinoid signalling
  • D. Piomelli
  • Medicine, Biology
  • Nature Reviews Neuroscience
  • 1 November 2003
The endocannabinoids are a family of lipid messengers that engage the cell surface receptors that are targeted by Δ9-tetrahydrocannabinol, the active principle in marijuana (Cannabis). They are madeExpand
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Modulation of anxiety through blockade of anandamide hydrolysis
The psychoactive constituent of cannabis, Δ9-tetrahydrocannabinol, produces in humans subjective responses mediated by CB1 cannabinoid receptors, indicating that endogenous cannabinoids mayExpand
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Role of endogenous cannabinoids in synaptic signaling.
Research of cannabinoid actions was boosted in the 1990s by remarkable discoveries including identification of endogenous compounds with cannabimimetic activity (endocannabinoids) and the cloning ofExpand
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A second endogenous cannabinoid that modulates long-term potentiation
Cannabinoid receptors are molecular targets for marijuana and hashish, the widespread drugs of abuse. These receptors are expressed in areas of the central nervous system that contribute in importantExpand
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Brain monoglyceride lipase participating in endocannabinoid inactivation
The endogenous cannabinoids (endocannabinoids) are lipid molecules that may mediate retrograde signaling at central synapses and other forms of short-range neuronal communication. The monoglycerideExpand
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Identification and Functional Characterization of Brainstem Cannabinoid CB2 Receptors
The presence and function of CB2 receptors in central nervous system (CNS) neurons are controversial. We report the expression of CB2 receptor messenger RNA and protein localization on brainstemExpand
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Control of pain initiation by endogenous cannabinoids
The potent analgesic effects of cannabis-like drugs and the presence of CB1-type cannabinoid receptors in pain-processing areas of the brain and spinal cord, indicate that endogenous cannabinoidsExpand
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An endocannabinoid mechanism for stress-induced analgesia
Acute stress suppresses pain by activating brain pathways that engage opioid or non-opioid mechanisms. Here we show that an opioid-independent form of this phenomenon, termed stress-inducedExpand
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Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α
Oleylethanolamide (OEA) is a naturally occurring lipid that regulates satiety and body weight. Although structurally related to the endogenous cannabinoid anandamide, OEA does not bind to cannabinoidExpand
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Characterization of the Fatty Acid Amide Hydrolase Inhibitor Cyclohexyl Carbamic Acid 3′-Carbamoyl-biphenyl-3-yl Ester (URB597): Effects on Anandamide and Oleoylethanolamide Deactivation
Fatty acid amide hydrolase (FAAH) is an intracellular serine enzyme that catalyzes the hydrolysis of bioactive fatty acid ethanolamides such as anandamide and oleoylethanolamide (OEA). GeneticExpand
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