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Cocaine receptors on dopamine transporters are related to self-administration of cocaine.
It is shown here that the potencies of cocaine-like drugs in self-administration studies correlate with their potencies in inhibiting [3H]mazindol binding to the dopamine transporters in the rat striatum, but not with theirPotencies in binding to a large number of other presynaptic and postsynaptic binding sites.
Correction for Gobbi et al., Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis
- G. Gobbi, F. Bambico, D. Piomelli
- BiologyProceedings of the National Academy of Sciences…
- 18 December 2005
It is shown that URB597, a selective inhibitor of the enzyme fatty-acid amide hydrolase, which catalyzes the intracellular hydrolysis of the endocannabinoid anandamide, exerts potent antidepressant-like effects in the mouse tail-suspension test and the rat forced-swim test.
Powerful Cocaine-Like Actions of 3,4-Methylenedioxypyrovalerone (MDPV), a Principal Constituent of Psychoactive ‘Bath Salts’ Products
The data show that MDPV is a monoamine transporter blocker with increased potency and selectivity for catecholamines when compared with cocaine, and may provide a mechanism to explain the adverse effects observed in humans taking high doses of ‘bath salts’ preparations.
Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1–A2A Receptor Heteromers
It is demonstrated that heteromerization of adenosine A1 receptors and A2A receptors allowsAdenosine to exert a fine-tuning modulation of glutamatergic neurotransmission and that chronic caffeine treatment leads to modifications in the function of the A1R–A2AR heteromer that could underlie the strong tolerance to the psychomotor effects of caffeine.
Nicotine induces conditioned place preferences over a large range of doses in rats
Small preferences for one side of the apparatus played a major role in the development of nicotine-induced CPP, suggesting that biased procedures may be more suitable than unbiased procedures for evaluation of rewarding effects of nicotine using CPP paradigms.
Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys
Monkeys show persistent intravenous self-administration behavior by monkeys for doses of THC lower than doses used in previous studies, but comparable to doses in marijuana smoke inhaled by humans.
Striatal Adenosine A2A and Cannabinoid CB1 Receptors Form Functional Heteromeric Complexes that Mediate the Motor Effects of Cannabinoids
It is reported that CB1 and adenosine A2A receptors form heteromeric complexes in co-transfected HEK-293T cells and rat striatum, where they colocalize in fibrilar structures and counteracted the motor depressant effects produced by the intrastriatal administration of a cannabinoid CB1 receptor agonist.
Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: Implications for striatal neuronal function
- S. Ferré, M. Karcz-Kubicha, F. Ciruela
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 20 August 2002
The results suggest that a functional mGluR5/A2AR interaction is required to overcome the well-known strong tonic inhibitory effect of dopamine on striatal adenosine A2AR function.
Two Brain Sites for Cannabinoid Reward
- A. Zangen, M. Solinas, S. Ikemoto, S. Goldberg, R. Wise
- Biology, PsychologyThe Journal of Neuroscience
- 3 May 2006
These findings link the sites of rewarding action of Δ9THC to brain regions where such drugs as amphetamines, cocaine, heroin, and nicotine are also thought to have their sites of reward action.
Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors.
Using a passive-avoidance task in rats, it is found that memory acquisition was enhanced by the FAAH inhibitor URB597 or by the PPAR-alpha agonist WY14643, and these enhancements were blocked by thePPAR- alpha antagonist MK886.