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PEP005

Known as: PEP 005, PEP-005 
National Institutes of Health

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2 relations

Broader (2)

3-ingenyl angelateingenol mebutate

Papers overview

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2020
2020
Modelling Parkinson disease
Low bodily sodium levels can lead to a rise in sodium appetite but how is the drive to ingest sodium regulated to prevent… 
2011
2011
Protein Kinase C and Anaplastic Lymphoma Kinase Targeted Compounds
3 
Review
2011
Review
2011
[What's new in dermato-oncology?].
2010
2010
Novel Antileukemic Compound Ingenol 3-Angelate Inhibits T Cell Apoptosis by Activating Protein Kinase Cθ*
Members of the protein kinase C (PKC) family of serine-threonine kinases are important regulators of immune cell survival… 
2010
2010
Abstract 1777: The skin cancer chemotherapeutic agent PEP005 is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature
Ingenol-3-angelate (PEP005), extracted from Euphorbia peplus, is currently in clinical trials for eradicating basal cell… 
2009
2009
Immunostimulatory cancer chemotherapy using local ingenol-3-angelate and synergy with immunotherapies.
2009
2009
The protein kinase C agonist PEP005 increases NF‐κB expression, induces differentiation and increases constitutive chemokine release by primary acute myeloid leukaemia cells
Acute myeloid leukaemia (AML) cells show constitutive release of several chemokines that occurs in three major clusters: (I… 
2007
2007
T cells remaining after intensive chemotherapy for acute myelogenous leukemia show a broad cytokine release profile including high levels of interferon-γ that can be further increased by a novel…
Cytokines are released during T cell activation, including the potentially anti-leukemic interferon-γ (IFNγ), but also the… 
2006
2006
Pathway Hyperactivation of the Mitogen-activated Protein Kinase Dependent − Melanoma Cells via Protein Kinase C Treated − Induction of Senescence in Diterpene Ester Material Supplementary Cited…
The diterpene ester PEP005 is a novel anticancer agent that activates protein kinase C (PKC) and induces cell death in melanoma… 
2003
2003
The measurement of PEP005 in human whole blood by HPLC-electrospray-tandem mass spectrometry
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