ingenol mebutate

Known as: 2-Butenoic acid, 2-methyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a- octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a- methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, (2Z)- 
A selective small-molecule activator of protein kinase C (PKC) isolated from the plant Euphorbia peplus with potential antineoplastic activity… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1974-2017
0204019742017

Papers overview

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2015
2015
Ingenol-mebutate has been used for the treatment of actinic keratosis. It has been shown that ingenol-mebutate inhibits the… (More)
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2015
2015
Topically applied ingenol mebutate (IngMeb) is approved for field-treatment of actinic keratosis and is currently being… (More)
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2013
2013
Actinic keratosis (AK) is a common ultraviolet light-induced skin lesion found on sun-exposed skin areas generally in older, fair… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Actinic keratosis is a common precursor to sun-related squamous-cell carcinoma. Treating actinic keratoses and the… (More)
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2012
2012
The incidence of nonmelanoma skin cancer continues to increase. While surgical excision remains the mainstay of treatment… (More)
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2012
2012
Skin cancer is the most prevalent cancer worldwide and is primarily caused by chronic UV exposure. Here, we describe the topical… (More)
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2012
2012
We investigated the proposed necrotic mechanism of ingenol mebutate, a natural compound with anti-cancer properties in human… (More)
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2010
2010
OBJECTIVES To evaluate the safety of two applications of PEP005 (ingenol mebutate) gel in superficial basal cell carcinoma… (More)
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2009
2009
BACKGROUND There is a need for improved medical approaches to the treatment of actinic keratosis. Ingenol mebutate, a diterpene… (More)
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2009
2009
The sap of the plant Euphorbia peplus is a traditional remedy for skin conditions, including actinic keratosis. The active… (More)
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