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Single Cell Profiling of Potentiated Phospho-Protein Networks in Cancer Cells
SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells.
Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia
Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia and their role in cell reprograming is described.
Subclassification of patients with acute myelogenous leukemia based on chemokine responsiveness and constitutive chemokine release by their leukemic cells.
Differences in chemokine responsiveness as well as Chemokine release contribute to patient heterogeneity in AML.
Acute Myeloid Leukemia with the t(8;21) Translocation: Clinical Consequences and Biological Implications
- H. Reikvam, K. Hatfield, A. Kittang, R. Hovland, Ø. Bruserud
- Biology, MedicineJournal of biomedicine & biotechnology
- 3 May 2011
The t(8;21) abnormality occurs in a minority of acute myeloid leukemia (AML) patients. The translocation results in an in-frame fusion of two genes, resulting in a fusion protein of one N-terminal…
Cytokine accumulation in photochemically treated and gamma‐irradiated platelet concentrates during storage
BACKGROUND: Photochemical treatment (PCT) for pathogen reduction of platelet concentrates (PCs) affects all cells containing DNA and/or RNA. Soluble mediators, which may cause transfusion reactions,…
Hematopoietic engraftment of dimethyl sulfoxide–depleted autologous peripheral blood progenitor cells
Investigation was to investigate whether DMSO depletion by manual single wash reduced frequency of adverse effects or had detrimental effects on the engraftment potential of peripheral blood progenitor cell (PBPC) autografts.
The crosstalk between the matrix metalloprotease system and the chemokine network in acute myeloid leukemia.
The different members of the MMP family are introduced and their interactions with the chemokine network are described and the possible involvement of MMPs together with chemokines in leukemogenesis and chemosensitivity in AML is described.
Histone deacetylase inhibitors in cancer treatment: a review of the clinical toxicity and the modulation of gene expression in cancer cell.
- Ø. Bruserud, C. Stapnes, E. Ersvaer, B. Gjertsen, A. Ryningen
- Biology, MedicineCurrent pharmaceutical biotechnology
Divergent effects of HDAC inhibition on the global gene expression profiles have been described when testing various cancer cells, and this is further complicated by altered HDAC expression induced by HDAC inhibitors.
The viability of cryopreserved PBPC depends on the DMSO concentration and the concentration of nucleated cells in the graft.
It is concluded that 5% DMSO may be the optimal dose for cryopreserving PBPC as long as the cells have not been concentrated at much more than 200 x 10(6) nucleated cells/mL.