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PEA15 wt Allele

Known as: Phosphoprotein Enriched In Astrocytes, 15kD Gene, Phosphoprotein Enriched In Astrocytes 15 wt Allele, RP11-536C5.8 
Human PEA15 wild-type allele is located in the vicinity of 1q21.1 and is approximately 10 kb in length. This allele, which encodes astrocytic… 
National Institutes of Health

Related topics

Related topics

5 relations
Diabetes Mellitus, Non-Insulin-DependentGlucose Transport InhibitionNegative Regulation of ApoptosisPEA15 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Protein Kinase B/Akt Binds and Phosphorylates PED/PEA-15, Stabilizing Its Antiapoptotic Action
ABSTRACT The antiapoptotic protein PED/PEA-15 features an Akt phosphorylation motif upstream from Ser116. In vitro, recombinant… 
Highly Cited
2000
Highly Cited
2000
swi1 and swi3 Perform Imprinting, Pausing, and Termination of DNA Replication in S. pombe
Highly Cited
2000
Highly Cited
2000
Differential gene expression by endothelial cells in distinct angiogenic states.
Angiogenesis is a complex process that can be regarded as a series of sequential events comprising a variety of tissue cells. The… 
Highly Cited
1999
Highly Cited
1999
PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis
PED/PEA-15 is a recently cloned 15 kDa protein possessing a death effector domain (DED). In MCF-7 and HeLa cells, a fivefold… 
Highly Cited
1999
Highly Cited
1999
Orientation of DNA replication establishes mating-type switching pattern in S. pombe
The fission yeast Schizosaccharomyces pombe normally has haploid cells of two mating types, which differ at the chromosomal locus… 
Highly Cited
1999
Highly Cited
1999
Knock-Out of the Neural Death Effector Domain Protein PEA-15 Demonstrates That Its Expression Protects Astrocytes from TNFα-Induced Apoptosis
Apoptosis is a very general phenomenon, but only a few reports concern astrocytes. Indeed, astrocytes express receptors for tumor… 
Highly Cited
1998
Highly Cited
1998
Endothelin Induces a Calcium‐Dependent Phosphorylation of PEA‐15 in Intact Astrocytes: Identification of Ser104 and Ser116 Phosphorylated, Respectively, by Protein Kinase C and Calcium/Calmodulin…
Abstract: PEA‐15 (phosphoprotein enriched in astrocytes, Mr = 15,000) is an acidic serine‐phosphorylated protein highly expressed… 
Highly Cited
1998
Highly Cited
1998
The Death Effector Domain of PEA-15 Is Involved in Its Regulation of Integrin Activation*
Increased integrin ligand binding affinity (activation) is triggered by intracellular signaling events. A Ras-initiated mitogen… 
Highly Cited
1995
Highly Cited
1995
MAT1 (‘menage à trois’) a new RING finger protein subunit stabilizing cyclin H‐cdk7 complexes in starfish and Xenopus CAK.
The kinase responsible for Thr161‐Thr160 phosphorylation and activation of cdc2/cdk2 (CAK:cdk‐activating kinase) has been shown… 
Highly Cited
1993
Highly Cited
1993
Characterization of PEA-15, a major substrate for protein kinase C in astrocytes.
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