FAQ

PDX1 gene

Known as: IDX-1, PANCREAS/DUODENUM HOMEOBOX PROTEIN 1, Pancreatic and Duodenal Homeobox 1 Gene 
This gene plays a role in the regulation of insulin and insulin-responsive genes.

Topic mentions per year

Topic mentions per year

1991-2017
0102019912017

Related topics

Related topics

9 relations
Carbohydrate MetabolismCell Differentiation processHomo sapiensPDX1 protein, human
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
PDX1 gene
Cell Differentiation process
dna binding
Homo sapiens
Carbohydrate Metabolism
Transcriptional Regulation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Reprogramming of pancreatic exocrine cells towards a beta (β) cell character using Pdx1, Ngn3 and MafA
Pdx1 (pancreatic and duodenal homeobox 1), Ngn3 (neurogenin 3) and MafA (v-maf musculoaponeurotic fibrosarcoma oncogene family… (More)
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2009
2009
Genome-Wide Linkage and Admixture Mapping of Type 2 Diabetes in African American Families From the American Diabetes Association GENNID (Genetics of NIDDM) Study Cohort
OBJECTIVE We used a single nucleotide polymorphism (SNP) map in a large cohort of 580 African American families to identify… (More)
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Highly Cited
2008
Highly Cited
2008
Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.
The onset of pancreas development in the foregut endoderm is marked by activation of the homeobox gene Pdx1 (IPF1). Pdx1 is… (More)
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2008
2008
Prenatal nicotine exposure alters early pancreatic islet and adipose tissue development with consequences on the control of body weight and glucose metabolism later in life.
Despite medical advice, 20-30% of female smokers continue to smoke during pregnancy. Epidemiological studies have associated… (More)
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2008
2008
Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome.
Metabolic syndrome is a risk factor for cardiovascular disease. The aim of the present study was to identify genetic variants… (More)
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Highly Cited
1997
Highly Cited
1997
Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence
The homeodomain protein IPF1 (also known as IDX1, STF1 and PDX1; see Methods) is critical for development of the pancreas in mice… (More)
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1996
1996
Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1.
Insulin promoter factor 1 (IPF1), a member of the homeodomain protein family, serves an early role in pancreas formation, as… (More)
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1995
1995
IPF1, a homeodomain protein with a dual function in pancreas development.
Insulin promoter factor 1 (IPF1), is a homeodomain protein which, in the adult mouse pancreas, is selectively expressed in beta… (More)
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1994
1994
Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes.
Insulin gene transcription is a unique feature of the pancreatic beta cells and is increased in response to glucose. The recent… (More)
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Highly Cited
1993
Highly Cited
1993
IPF1, a homeodomain-containing transactivator of the insulin gene.
We describe the cloning of insulin promoter factor 1 (IPF1), a homeodomain protein which in the adult mouse pancreas is… (More)
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