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Initiation and execution of lipotoxic ER stress in pancreatic β-cells
Saturated FFA induce ER stress via ER Ca2+ depletion and the IRE1 and resulting JNK activation contribute to β-cell apoptosis, suggesting that ER stress in primary β-cells is primarily lipotoxic, and not glucolipotoxic.
Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming.
- L. S. Jouaville, P. Pinton, C. Bastianutto, G. Rutter, R. Rizzuto
- BiologyProceedings of the National Academy of Sciences…
- 23 November 1999
A direct role of mitochondrial Ca(2+) in driving ATP production is demonstrated and a form of cellular memory is unraveled that allows a prolonged metabolic activation in stimulated cells.
Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose
Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes–Associated Variants
ZnT8 is required for normal insulin crystallization and insulin release in vivo but not, remarkably, in vitro, and defects in the former processes in carriers of the R allele may increase type 2 diabetes risks.
The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus.
Better understanding of the role of oxidative changes, its modulation by genes involved in disease risk, and effects on beta-cell identity may facilitate the development of new therapeutic strategies to this disease.
Dense core secretory vesicles revealed as a dynamic Ca2+ store in neuroendocrine cells with a vesicle-associated membrane protein aequorin chimaera
Secretory vesicle-associated membrane protein 2–synaptobrevin represents a dynamic Ca2+ store in neuroendocrine cells, whose characteristics are in part distinct from the ER/Golgi apparatus.
MicroRNA-124a Regulates Foxa2 Expression and Intracellular Signaling in Pancreatic β-Cell Lines*
The precise role of microRNA-124a2 in pancreatic development remains to be deciphered, but it is identified as a regulator of a key transcriptional protein network in β-cells responsible for modulating intracellular signaling.
Mechanisms of Dense Core Vesicle Recapture following “Kiss and Run” (“Cavicapture”) Exocytosis in Insulin-secreting Cells*
It is concluded that re-uptake of vesicles after peptide release by cavicapture corresponds to a novel form of endocytosis in which dynamin-1 stabilizes and eventually closes the fusion pore, with no requirement for “classical” endocyTosis for retreat from the plasma membrane.
Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis
- Jan L. Vinkenborg, T. Nicolson, E. Bellomo, M. Koay, G. Rutter, M. Merkx
- BiologyNature Methods
- 1 October 2009
We developed genetically encoded fluorescence resonance energy transfer (FRET)-based sensors that display a large ratiometric change upon Zn2+ binding, have affinities that span the pico- to…
Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression.
- G. da Silva Xavier, I. Leclerc, A. Váradi, T. Tsuboi, S. Moule, G. Rutter
- Biology, MedicineBiochemical Journal
- 1 May 2003
Results indicate that inhibition of AMPK by glucose is essential for the activation of insulin secretion by the sugar, and may contribute to the transcriptional stimulation of the preproinsulin gene.