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PDE10A gene

Known as: PDE10A, PHOSPHODIESTERASE 10A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A.
2014
2014
Discovery and Development of 11C-Lu AE92686 as a Radioligand for PET Imaging of Phosphodiesterase10A in the Brain
Phosphodiesterase 10A (PDE10A) plays a key role in the regulation of brain striatal signaling, and several pharmaceutical… 
2013
2013
Quantification of 18F-JNJ-42259152, a Novel Phosphodiesterase 10A PET Tracer: Kinetic Modeling and Test–Retest Study in Human Brain
Phosphodiesterase 10A (PDE10A) plays a central role in striatal signaling and is implicated in several neuropsychiatric disorders… 
2012
2012
Stress history increases alcohol intake in relapse: relation to phosphodiesterase 10A
Stressful experiences can result in elevated alcohol drinking, as exemplified in many individuals with post‐traumatic stress… 
2012
2012
Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors.
2012
2012
Human biodistribution and dosimetry of 18F-JNJ42259152, a radioligand for phosphodiesterase 10A imaging
PurposePhosphodiesterase 10A (PDE10A) is a cAMP/cGMP-hydrolysing enzyme with a central role in striatal signalling and implicated… 
2011
2011
Use of structure-based design to discover a potent, selective, in vivo active phosphodiesterase 10A inhibitor lead series for the treatment of schizophrenia.
Utilizing structure-based virtual library design and scoring, a novel chimeric series of phosphodiesterase 10A (PDE10A… 
Highly Cited
2011
Highly Cited
2011
Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain.
Review
2009
Review
2009
Patented PDE10A inhibitors: novel compounds since 2007
Importance of the field: PDE10A inhibition has generated much excitement as a potential novel mechanism for the treatment of the… 
Review
2007
Review
2007
Role of phosphodiesterases in neurological and psychiatric disease.
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