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PET visualization of microglia in multiple sclerosis patients using [11C]PK11195
Activated microglia are involved in the immune response of multiple sclerosis (MS). The peripheral benzodiazepine receptor (PBR) is expressed on microglia and up‐regulated after neuronal injury.… Expand
Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
IMPORTANCE Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons… Expand
Paroxysmal exercise-induced dyskinesia and epilepsy is due to mutations in SLC2A1, encoding the glucose transporter GLUT1
- A. Suls, P. Dedeken, +24 authors W. Van Paesschen
- Biology, Medicine
- Brain : a journal of neurology
- 26 June 2008
Paroxysmal exercise-induced dyskinesia (PED) can occur in isolation or in association with epilepsy, but the genetic causes and pathophysiological mechanisms are still poorly understood. We performed… Expand
Value of 18fluorodeoxyglucose-positron-emission tomography in amyotrophic lateral sclerosis: a prospective study.
IMPORTANCE Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder primarily affecting the motor system, with extramotor involvement to a variable extent. Biomarkers for early… Expand
[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor
- H. Burns, K. Van Laere, +26 authors R. Hargreaves
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 5 June 2007
[18F]MK-9470 is a selective, high-affinity, inverse agonist (human IC50, 0.7 nM) for the cannabinoid CB1 receptor (CB1R) that has been developed for use in human brain imaging. Autoradiographic… Expand
Phase 1 Study of the Pittsburgh Compound B Derivative 18F-Flutemetamol in Healthy Volunteers and Patients with Probable Alzheimer Disease
- N. Nelissen, K. Van Laere, +6 authors R. Vandenberghe
- Journal of Nuclear Medicine
- 1 August 2009
11C-Pittsburgh compound B (PiB) marks Aβ amyloidosis, a key pathogenetic process in Alzheimer disease (AD). The use of 11C-PiB is limited to centers with a cyclotron. Development of the 18F-labeled… Expand
Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis.
IMPORTANCE Amyloid-β positron emission tomography (PET) imaging allows in vivo detection of fibrillar plaques, a core neuropathological feature of Alzheimer disease (AD). Its diagnostic utility is… Expand
SPECT neuropsychological activation procedure with the Verbal Fluency Test in attempted suicide patients
- I. Goethals, K. Van Laere, +6 authors R. Dierckx
- Nuclear medicine communications
- 1 September 2002
Performance on the Verbal Fluency Test, as a measure of the ability of initiating processes, is reduced in depressed suicidal patients. The hampered results in this prefrontal executive task parallel… Expand
Prefrontal 5-HT2a receptor binding index, hopelessness and personality characteristics in attempted suicide.
- C. van Heeringen, K. Audenaert, +4 authors R. Dierckx
- Medicine, Psychology
- Journal of affective disorders
- 1 April 2003
BACKGROUND Depression, hopelessness, impaired problem solving capacities and deficient serotonergic functions have been identified as major causes of suicidal behaviour. In general, the relation… Expand
Assessment of Neuroinflammation and Microglial Activation in Alzheimer’s Disease with Radiolabelled PK11195 and Single Photon Emission Computed Tomography
Objectives: Inflammation contributes to degeneration in Alzheimer’s disease (AD), not simply as a secondary phenomenon, but primarily as a significant source of pathology. [123I]iodo-PK11195 is a… Expand