PDC gene

Known as: PHOSDUCIN, MEKA, PDC 
This gene plays a role in cell signaling and the regulation of phototransduction.
National Institutes of Health

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PDC wt Allele
PDC, veterinary productSignal TransductionVisual Perceptionphosducin

Papers overview

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2008
2008
Dopamine modulates diurnal and circadian rhythms of protein phosphorylation in photoreceptor cells of mouse retina.
Many aspects of photoreceptor metabolism are regulated as diurnal or circadian rhythms. The nature of the signals that drive… (More)
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2006
2006
Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex.
Phosducin-like protein (PhLP) is a widely expressed binding partner of the G protein betagamma subunit complex (Gbetagamma) that… (More)
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2006
2006
PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates.
Many ATP-dependent molecular chaperones, including Hsp70, Hsp90, and the chaperonins GroEL/Hsp60, require cofactor proteins to… (More)
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Highly Cited
2004
Highly Cited
2004
Expression of cone-photoreceptor-specific antigens in a cell line derived from retinal tumors in transgenic mice.
PURPOSE To examine an immortalized mouse retinal cell line (661W) for markers characteristic of photoreceptor cells and validate… (More)
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Highly Cited
2002
Highly Cited
2002
Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis.
While the pathologic mechanisms responsible for organ-specific tissue damage in primary biliary cirrhosis (PBC) remain an enigma… (More)
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Highly Cited
2002
Highly Cited
2002
Identification of HLA-A2–restricted CD8+ Cytotoxic T Cell Responses in Primary Biliary Cirrhosis
Primary biliary cirrhosis (PBC) is characterized by an intense biliary inflammatory CD4(+) and CD8(+) T cell response. Very… (More)
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2001
2001
Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein betagamma subunits is used for recognition of a subclass of effectors.
To understand the requirements for binding to G protein betagamma subunits, phage-displayed random peptide libraries were… (More)
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Highly Cited
1999
Highly Cited
1999
Morphological, physiological, and biochemical changes in rhodopsin knockout mice.
Mutations in rod opsin, the visual pigment protein of rod photoreceptors, account for approximately 15% of all inherited human… (More)
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1999
1999
Effects of the neurotrophin brain-derived neurotrophic factor in an experimental model of retinal detachment.
PURPOSE To examine the effects of brain-derived neurotrophic factor (BDNF) in an animal model of retinal detachment. METHODS… (More)
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1998
1998
Phosducin induces a structural change in transducin beta gamma.
BACKGROUND Phosducin binds tightly to the beta gamma subunits (Gt beta gamma) of the heterotrimeric G protein transducin… (More)
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