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PDC gene

Known as: PHOSDUCIN, MEKA, PDC 
This gene plays a role in cell signaling and the regulation of phototransduction.
National Institutes of Health

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PDC wt Allele
PDC, veterinary productSignal TransductionVisual Perceptionphosducin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Expression of cone-photoreceptor-specific antigens in a cell line derived from retinal tumors in transgenic mice.
PURPOSE To examine an immortalized mouse retinal cell line (661W) for markers characteristic of photoreceptor cells and validate… 
Highly Cited
2004
Highly Cited
2004
Phosducin Facilitates Light-driven Transducin Translocation in Rod Photoreceptors
Phosducin is a photoreceptor-specific protein known to interact with the βγ subunits of G proteins. In pursuit of the function of… 
Highly Cited
2002
Highly Cited
2002
Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis.
While the pathologic mechanisms responsible for organ-specific tissue damage in primary biliary cirrhosis (PBC) remain an enigma… 
Highly Cited
2002
Highly Cited
2002
Identification of HLA-A2–restricted CD8+ Cytotoxic T Cell Responses in Primary Biliary Cirrhosis
Primary biliary cirrhosis (PBC) is characterized by an intense biliary inflammatory CD4+ and CD8+ T cell response. Very limited… 
Highly Cited
1999
Highly Cited
1999
Morphological, physiological, and biochemical changes in rhodopsin knockout mice.
Mutations in rod opsin, the visual pigment protein of rod photoreceptors, account for approximately 15% of all inherited human… 
Highly Cited
1999
Highly Cited
1999
Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases.
Homologous desensitization of G protein-coupled receptors is thought to occur in several steps: binding of G protein-coupled… 
Highly Cited
1996
Highly Cited
1996
Crystal Structure at 2.4 Å Resolution of the Complex of Transducin βγ and Its Regulator, Phosducin
Highly Cited
1994
Highly Cited
1994
The phosphorylation state of phosducin determines its ability to block transducin subunit interactions and inhibit transducin binding to activated rhodopsin.
Highly Cited
1992
Highly Cited
1992
Phosducin is a protein kinase A-regulated G-protein regulator
SIGNAL transduction by G-protein-coupled receptors is regulated by various mechanisms acting at the receptor level; those studied… 
Highly Cited
1992
Highly Cited
1992
Regulation of retinal cGMP cascade by phosducin in bovine rod photoreceptor cells. Interaction of phosducin and transducin.
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