PDC gene

Members of the phosducin gene family were initially proposed to act as down-regulators of G protein signaling by binding G… Expand

PURPOSE To examine an immortalized mouse retinal cell line (661W) for markers characteristic of photoreceptor cells and validate… Expand

Phosducin is a photoreceptor-specific protein known to interact with the βγ subunits of G proteins. In pursuit of the function of… Expand

While the pathologic mechanisms responsible for organ-specific tissue damage in primary biliary cirrhosis (PBC) remain an enigma… Expand

Mutations in rod opsin, the visual pigment protein of rod photoreceptors, account for approximately 15% of all inherited human… Expand

Homologous desensitization of G protein-coupled receptors is thought to occur in several steps: binding of G protein-coupled… Expand

Abstract The crystal structure of transducin's βγ subunits complexed with phosducin, which regulates G t βγ activity, has been… Expand

Heterotrimeric GTP-binding proteins (G-proteins) serve many different signal transduction pathways. Phosducin, a 28-kDa… Expand

SIGNAL transduction by G-protein-coupled receptors is regulated by various mechanisms acting at the receptor level; those studied… Expand

Photoexcitation of retinal rod photoreceptor cells involves the activation of cGMP enzyme cascade in which sequential activation… Expand