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Transient, genetic elimination of a specialized group of cells called plasmacytoid dendritic cells (pDCs) reverses many features… Expand Infections with persistent viruses are a frequent cause of immunosuppression, autoimmune sequelae, and/or neoplastic disease… Expand Plasmacytoid dendritic cells (pDCs) mediate type I interferon (IFN-I) responses to viruses that are recognized through the Toll… Expand ABSTRACT Type I interferon (IFN) induction is an immediate response to virus infection, and very high levels of these cytokines… Expand PURPOSE
The recent identification of toll-like receptors (TLRs) and respective ligands allows the evaluation of novel dendritic… Expand HIV-1 directly activates human plasmacytoid DCs (pDCs) by upregulating the expression of costimulatory and MHC molecules and… Expand Antiviral cell–mediated immunity is initiated by the dendritic cell (DC) network in lymph nodes (LNs). Plasmacytoid DCs (pDCs… Expand Dendritic cell (DC) precursors were propagated from C57BL/10 (B10; H2b) mouse bone marrow in fms‐like tyrosine kinase 3 ligand… Expand The recruitment of selected dendritic cell (DC) subtypes conditions the class of the immune response. Here we show that the… Expand To study the role of glutamate uptake at central glutamatergic synapses, we used the uptake blocker L-transpyrrolidine-2,4… Expand