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PD 169316

Known as: 4-(4-fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole, PD-169316, PD169316 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Enzyme InhibitorsImidazoles

Papers overview

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Highly Cited
2011
Highly Cited
2011
Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling.
Lysyl oxidase (LOX) is a key extracellular enzyme responsible for the post-translational modification of collagens I and III to… Expand
Highly Cited
2006
Highly Cited
2006
Inhibition of p38MAPK increases adipogenesis from embryonic to adult stages.
Formation of new adipocytes from precursor cells contributes to adipose tissue expansion and obesity. In this study, we asked… Expand
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Highly Cited
2005
Highly Cited
2005
A Role for p38 Mitogen-Activated Protein Kinase in the Regulation of the Serotonin Transporter: Evidence for Distinct Cellular Mechanisms Involved in Transporter Surface Expression
The serotonin transporter (SERT) is regulated by various signaling mechanisms that may operate to maintain appropriate levels of… Expand
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Highly Cited
2004
Highly Cited
2004
Phosphorylation of p38 MAPK Induced by Oxidative Stress Is Linked to Activation of Both Caspase-8- and -9-mediated Apoptotic Pathways in Dopaminergic Neurons*
We evaluated the contribution of p38 mitogen-activated protein kinase and the events upstream/downstream of p38 leading to… Expand
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Highly Cited
2003
Highly Cited
2003
Up-regulation of Cyclooxygenase-2 and Apoptosis Resistance by p38 MAPK in Hypericin-mediated Photodynamic Therapy of Human Cancer Cells*
Photodynamic Therapy (PDT) is an approved anticancer therapy that kills cancer cells by the photochemical generation of reactive… Expand
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Highly Cited
2002
Highly Cited
2002
Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications.
The transcription factor nuclear factor-kappaB (NF-kappaB) confers significant survival potential in a variety of tumors. Several… Expand
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Highly Cited
2002
Highly Cited
2002
ATM Mediates Phosphorylation at Multiple p53 Sites, Including Ser46, in Response to Ionizing Radiation*
The p53 tumor suppressor protein preserves genome integrity by regulating growth arrest and apoptosis in response to DNA damage… Expand
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Highly Cited
2001
Highly Cited
2001
Insulin signaling leading to proliferation, survival, and membrane ruffling in C2C12 myoblasts
We have recently shown that insulin induced myogenesis in the mouse C2C12 skeletal muscle cell line by activation of… Expand
Highly Cited
1999
Highly Cited
1999
The Activation of the c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase Signaling Pathways Protects HeLa Cells from Apoptosis Following Photodynamic Therapy with Hypericin*
In this study, we elucidate signaling pathways induced by photodynamic therapy (PDT) with hypericin. We show that PDT rapidly… Expand
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Highly Cited
1997
Highly Cited
1997
Apoptosis Induced by Withdrawal of Trophic Factors Is Mediated by p38 Mitogen-activated Protein Kinase*
p38 is a member of the mitogen-activated protein (MAP) kinase superfamily activated by stress signals and implicated in cellular… Expand
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