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PD 169316

Known as: 4-(4-fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole, PD-169316, PD169316 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Enzyme InhibitorsImidazoles

Papers overview

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Highly Cited
2011
Highly Cited
2011
Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling.
Lysyl oxidase (LOX) is a key extracellular enzyme responsible for the post-translational modification of collagens I and III to… Expand
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Highly Cited
2006
Highly Cited
2006
Inhibition of p38MAPK increases adipogenesis from embryonic to adult stages.
Formation of new adipocytes from precursor cells contributes to adipose tissue expansion and obesity. In this study, we asked… Expand
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Highly Cited
2005
Highly Cited
2005
A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression.
The serotonin transporter (SERT) is regulated by various signaling mechanisms that may operate to maintain appropriate levels of… Expand
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Highly Cited
2004
Highly Cited
2004
Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons.
We evaluated the contribution of p38 mitogen-activated protein kinase and the events upstream/downstream of p38 leading to… Expand
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Highly Cited
2004
Highly Cited
2004
Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner.
Insulin stimulation produced a reliable 3-fold increase in glucose uptake in primary neonatal rat myotubes, which was accompanied… Expand
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Highly Cited
2003
Highly Cited
2003
Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes.
Brown adipose tissue expresses the thermogenic uncoupling protein-1 (UCP-1), which is positively regulated by peroxisome… Expand
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Highly Cited
2002
Highly Cited
2002
Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications.
The transcription factor nuclear factor-kappaB (NF-kappaB) confers significant survival potential in a variety of tumors. Several… Expand
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Highly Cited
2002
Highly Cited
2002
ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation.
The p53 tumor suppressor protein preserves genome integrity by regulating growth arrest and apoptosis in response to DNA damage… Expand
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Highly Cited
2001
Highly Cited
2001
Insulin signaling leading to proliferation, survival, and membrane ruffling in C2C12 myoblasts.
We have recently shown that insulin induced myogenesis in the mouse C2C12 skeletal muscle cell line by activation of… Expand
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Highly Cited
1997
Highly Cited
1997
Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase.
p38 is a member of the mitogen-activated protein (MAP) kinase superfamily activated by stress signals and implicated in cellular… Expand
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