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PD 169316

Known as: 4-(4-fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole, PD-169316, PD169316 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Enzyme InhibitorsImidazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Activation of p38/JNK Pathway Is Responsible for Embelin Induced Apoptosis in Lung Cancer Cells: Transitional Role of Reactive Oxygen Species
The natural product embelin has been demonstrated to possess a wide range of therapeutic properties, however, the mechanisms by… 
2012
2012
Bioluminescence methodology for the detection of protein-protein interactions within the voltage-gated sodium channel macromolecular complex.
Protein-protein interactions are critical molecular determinants of ion channel function and emerging targets for pharmacological… 
Highly Cited
2005
Highly Cited
2005
Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of cell signaling inhibitors and apoptotic effects of B[a]P metabolites.
Highly Cited
2004
Highly Cited
2004
Opposite effects of Ha-Ras and Ki-Ras on radiation-induced apoptosis via differential activation of PI3K/Akt and Rac/p38 mitogen-activated protein kinase signaling pathways
It has been well known that Ras signaling is involved in various cellular processes, including proliferation, differentiation… 
Highly Cited
2003
Highly Cited
2003
Prion Protein Fragment 106–126 Induces a p38 MAP Kinase—Dependent Apoptosis in SH‐SY5Y Neuroblastoma Cells Independently from the Amyloid Fibril Formation
Abstract: Prion diseases are neurodegenerative disorders of the central nervous system of humans and animals, characterized by… 
2002
2002
Cyclooxygenase-2 Expression in Cultured Cortical Thick Ascending Limb of Henle Increases in Response to Decreased Extracellular Ionic Content by Both Transcriptional and Post-transcriptional…
We showed previously that decreased extracellular salt or chloride up-regulates the cortical thick ascending limb of Henle (cTALH… 
Highly Cited
2002
Highly Cited
2002
Divergent regulation by p44/p42 MAP kinase and p38 MAP kinase of bone morphogenetic protein‐4‐stimulated osteocalcin synthesis in osteoblasts
In the present study, we investigated whether the mitogen‐activated protein (MAP) kinase superfamily is involved in the bone… 
Highly Cited
2000
Highly Cited
2000
Arachidonic Acid Activates Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase 2 and Mediates Adhesion of a Human Breast Carcinoma Cell Line to Collagen Type IV through a p38 MAP Kinase…
Adhesion of metastatic human mammary carcinoma MDA-MB-435 cells to the basement membrane protein collagen type IV can be… 
2000
2000
Haloperidol‐Induced Neuronal Apoptosis
Abstract: We examined patterns and mechanisms of cell death inducedby haloperidol. Cortical cell cultures exposed to 10‐100… 
2000
2000
Endothelin-1 induces vascular endothelial growth factor synthesis in osteoblasts: involvement of p38 mitogen-activated protein kinase.
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