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PD 169316

Known as: 4-(4-fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole, PD-169316, PD169316 
National Institutes of Health

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2 relations

Broader (2)

Enzyme InhibitorsImidazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Inhibition of p38 MAPK signaling in chondrocyte cultures results in enhanced osteogenic differentiation of perichondral cells.
Highly Cited
2005
Highly Cited
2005
Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of cell signaling inhibitors and apoptotic effects of B[a]P metabolites.
Highly Cited
2004
Highly Cited
2004
Opposite effects of Ha-Ras and Ki-Ras on radiation-induced apoptosis via differential activation of PI3K/Akt and Rac/p38 mitogen-activated protein kinase signaling pathways
It has been well known that Ras signaling is involved in various cellular processes, including proliferation, differentiation… 
Highly Cited
2004
Highly Cited
2004
All-trans retinoic acid potentiates Taxotere-induced cell death mediated by Jun N-terminal kinase in breast cancer cells
Taxotere is a cytotoxin effective in treating breast and prostate cancer. It stabilizes microtubules and causes catastrophic cell… 
2004
2004
Interleukin (IL)‐17 enhances tumor necrosis factor‐α‐stimulated IL‐6 synthesis via p38 mitogen‐activated protein kinase in osteoblasts
Inflammatory cytokines are well known to play crucial roles in the pathogenesis of rheumatoid arthritis. Among them, interleukin… 
Highly Cited
2003
Highly Cited
2003
Prion Protein Fragment 106–126 Induces a p38 MAP Kinase—Dependent Apoptosis in SH‐SY5Y Neuroblastoma Cells Independently from the Amyloid Fibril Formation
Abstract: Prion diseases are neurodegenerative disorders of the central nervous system of humans and animals, characterized by… 
2001
2001
Inhibitors of p38 MAP kinase increase the survival of transplanted dopamine neurons
2001
2001
Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons.
The mitogen-activated protein kinase (MAPK) cascades are thought to be important mediators in the transduction of extracellular… 
Highly Cited
2000
Highly Cited
2000
Arachidonic Acid Activates Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase 2 and Mediates Adhesion of a Human Breast Carcinoma Cell Line to Collagen Type IV through a p38 MAP Kinase…
Adhesion of metastatic human mammary carcinoma MDA-MB-435 cells to the basement membrane protein collagen type IV can be… 
2000
2000
Endothelin-1 induces vascular endothelial growth factor synthesis in osteoblasts: involvement of p38 mitogen-activated protein kinase.
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