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PD 169316

Known as: 4-(4-fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole, PD-169316, PD169316 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
0102019972017

Related topics

Related topics

2 relations

Broader (2)

Enzyme InhibitorsImidazoles

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
PD 169316
Imidazoles
Enzyme Inhibitors

Papers overview

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Highly Cited
2009
Highly Cited
2009
Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway.
Oxidative stress-induced neuronal apoptosis is a prominent feature found in neurodegenerative disorders. However, how oxidative… (More)
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2006
2006
p38 mitogen-activated protein kinase activity commits embryonic stem cells to either neurogenesis or cardiomyogenesis.
Mouse embryonic stem (ES) cells can be differentiated, in vitro into a variety of cell types including cardiac cells and neurons… (More)
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Highly Cited
2005
Highly Cited
2005
A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression.
The serotonin transporter (SERT) is regulated by various signaling mechanisms that may operate to maintain appropriate levels of… (More)
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Highly Cited
2004
Highly Cited
2004
Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons.
We evaluated the contribution of p38 mitogen-activated protein kinase and the events upstream/downstream of p38 leading to… (More)
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Highly Cited
2002
Highly Cited
2002
ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation.
The p53 tumor suppressor protein preserves genome integrity by regulating growth arrest and apoptosis in response to DNA damage… (More)
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Highly Cited
2002
Highly Cited
2002
Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications.
The transcription factor nuclear factor-kappaB (NF-kappaB) confers significant survival potential in a variety of tumors. Several… (More)
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Highly Cited
2002
Highly Cited
2002
U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells.
Osteoclasts are multinucleated cells that differentiate from hematopoietic cells and possess characteristics responsible for bone… (More)
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2002
2002
A novel regulatory mechanism of the mitochondrial Ca2+ uniporter revealed by the p38 mitogen-activated protein kinase inhibitor SB202190.
It is widely acknowledged that mitochondrial Ca2+ uptake modulates the cytosolic [Ca2+] ([Ca2+]c) acting as a transient Ca2… (More)
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Highly Cited
2000
Highly Cited
2000
Role of p38 in the regulation of renal cortical cyclooxygenase-2 expression by extracellular chloride.
We have previously shown that in renal cortex, COX-2 expression is localized to macula densa and surrounding cortical thick… (More)
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Highly Cited
1997
Highly Cited
1997
Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase.
p38 is a member of the mitogen-activated protein (MAP) kinase superfamily activated by stress signals and implicated in cellular… (More)
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