Siti Mariam Zakaria

  • Citations Per Year
Learn More
SCF (Skp1/Cul1/F-box) ubiquitin ligases act as master regulators of cellular homeostasis by targeting key proteins for ubiquitylation. Here, we identified a hitherto uncharacterized F-box protein, FBXO28 that controls MYC-dependent transcription by non-proteolytic ubiquitylation. SCF(FBXO28) activity and stability are regulated during the cell cycle by(More)
The Myc oncoprotein is tightly regulated at multiple levels including ubiquitin-mediated protein turnover. We recently demonstrated that inhibition of Cdk2-mediated phosphorylation of Myc at Ser-62 pharmacologically or through interferon (IFN)-γ-induced expression of p27(Kip1) (p27) repressed Myc's activity to suppress cellular senescence and(More)
CDK‐mediated activation of the SCF ubiquitin ligase promotes MYC‐driven transcription and tumourigenesis and predicts poor survival in breast cancer Diana Cepeda, Hwee-Fang Ng1y, Hamid Reza Sharifi3y, Salah Mahmoudi1y, Vanessa Soto Cerrato4z, Erik Fredlund3z, Kristina Magnusson5z, Helén Nilsson3z, Alena Malyukova, Juha Rantala, Daniel Klevebring, Francesc(More)
  • 1