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Phosphorylation of αB-Crystallin in Response to Various Types of Stress*
Phosphorylation of αB-crystallin, a member of the hsp27 family, in human glioma (U373 MG) cells was stimulated by exposure of the cells to various stimuli, which included heat, arsenite, phorbolExpand
Sept8 controls the binding of vesicle‐associated membrane protein 2 to synaptophysin
Septins, a conserved family of GTP/GDP‐binding proteins, are present in organisms as diverse as yeast and mammals. We analyzed the distribution of five septins, Sept6, Sept7, Sept8, Sept9 and Sept11,Expand
Responses of Heat Shock Proteins hsp27, αB‐Crystallin, and hsp70 in Rat Brain After Kainic Acid‐Induced Seizure Activity
Abstract: We determined the changes in the levels of the mammalian small heat shock protein of 25‐28 kDa (hsp27) and the hsp αB‐crystallin in various regions of rat brain after kainic acid‐inducedExpand
Upregulation by retinoic acid of transforming growth factor-beta-stimulated heat shock protein 27 induction in osteoblasts: involvement of mitogen-activated protein kinases.
We investigated whether transforming growth factor-beta (TGF-beta) stimulates the induction of heat shock protein (HSP) 27 and HSP70 in osteoblast-like MC3T3-E1 cells and the mechanism underlying theExpand
Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27
Abstract We previously showed that the aggregated form of Hsp27 in cultured cells becomes dissociated as a result of phosphorylation with various types of stress. In order to clarify the signalExpand
Mechanism of simvastatin on induction of heat shock protein in osteoblasts.
It has recently been reported that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) stimulate bone formation. However, the mechanism of stimulation of bone metabolism by statinsExpand
Inhibition of proteasomes induces accumulation, phosphorylation, and recruitment of HSP27 and alphaB-crystallin to aggresomes.
Molecular chaperones and the ubiquitin-proteasome pathway are known to participate in the quality control of proteins in cells. In this study, we examined the responses of small heat shock proteinsExpand
Brain-derived neurotrophic factor, nerve growth factor and neurotrophin-3 in selected regions of the rat brain following kainic acid-induced seizure activity
Abstract Changes in levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3) in various regions of the rat brain following kainic acid-induced seizureExpand
A survey on exposure level, health status, and biomarkers in workers exposed to 1-bromopropane.
BACKGROUND The aim of this study was to evaluate the health effects of exposure mainly to 1-bromopropane, which is an alternative to ozone-depleting solvents, and to establish biomarkers forExpand
5-Aminolevulinic acid regulates the inflammatory response and alloimmune reaction.
5-Aminolevulinic acid (5-ALA) is a naturally occurring amino acid and precursor of heme and protoporphyrin IX (PpIX). Exogenously administrated 5-ALA increases the accumulation of PpIX in tumor cellsExpand
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