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PCSK6 gene

Known as: SPC4, PACE4, PAIRED BASIC AMINO ACID CLEAVING ENZYME 4 
National Institutes of Health

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PCSK4 gene

Papers overview

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Highly Cited
2013
Highly Cited
2013
Furin Is the Primary in Vivo Convertase of Angiopoietin-like 3 and Endothelial Lipase in Hepatocytes*
Background: Proprotein convertases (PCs) activate overexpressed endothelial lipase (EL) inhibitor angiopoietin-like-3 (ANGPTL3… 
Highly Cited
2012
Highly Cited
2012
Role of proprotein convertases in prostate cancer progression.
Better understanding of the distinct and redundant functions of the proprotein convertase (PC) enzyme family within… 
Highly Cited
2011
Highly Cited
2011
Molecular Validation of PACE4 as a Target in Prostate Cancer.
Prostate cancer remains the single most prevalent cancer in men. Standard therapies are still limited and include androgen… 
2010
2010
Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis.
PACE4 is a proprotein convertase (PC) responsible for cleaving and activating proteins that contribute to enhance tumor… 
Review
2008
Review
2008
Knock-out mouse models of proprotein convertases: unique functions or redundancy?
The members of the proprotein convertase family play a central role in the processing and/or activation of various protein… 
2004
2004
Identification of Prodomain Determinants Involved in ADAMTS-1 Biosynthesis*
The metalloprotease ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin type I motif), similarly to other members of… 
Highly Cited
2002
Highly Cited
2002
Proteolytic Processing of Familial British Dementia-associated BRI Variants
Different mutations in theBRI2 gene cause rare neurodegenerative conditions, termed familial British dementia (FBD) and familial… 
Highly Cited
1996
Highly Cited
1996
Increased proteolytic processing of protein tyrosine phosphatase mu in confluent vascular endothelial cells: the role of PC5, a member of the subtilisin family.
Cleavage and subsequent release of the extracellular domains of receptor protein tyrosine phosphatases (RPTP) occur at high cell… 
Highly Cited
1995
Highly Cited
1995
Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways
Highly Cited
1993
Highly Cited
1993
PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE.
Proteins that transit the constitutive pathway of secretion frequently require proteolytic processing after a pair of basic amino… 
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