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PCSK6 gene

Known as: SPC4, PACE4, PAIRED BASIC AMINO ACID CLEAVING ENZYME 4 
National Institutes of Health

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PCSK4 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
miR‐124 exhibits antiproliferative and antiaggressive effects on prostate cancer cells through PACE4 pathway
PACE4 plays an important role in prostate cancer (PCa) proliferation and aggression, which might provide a useful target against… 
Highly Cited
2012
Highly Cited
2012
Role of proprotein convertases in prostate cancer progression.
Better understanding of the distinct and redundant functions of the proprotein convertase (PC) enzyme family within… 
2010
2010
Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis.
PACE4 is a proprotein convertase (PC) responsible for cleaving and activating proteins that contribute to enhance tumor… 
Highly Cited
2005
Highly Cited
2005
PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression.
Collagen type IV degradation results in disruption and breakdown of the normal basement membrane architecture, a key process in… 
2003
2003
Epigenetic regulation of proprotein convertase PACE4 gene expression in human ovarian cancer cells.
Proprotein convertases (PC) are a family of serine endoproteases that play important roles in regulating cell function by… 
1999
1999
Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain.
PACE4 is a member of the eukaryotic subtilisin-like endoprotease family. The expression of human PACE4 in RPE.40 cells (furin… 
1998
1998
Biosynthetic processing and quaternary interactions of proprotein convertase SPC4 (PACE4)
Highly Cited
1997
Highly Cited
1997
Role of prohormone convertases in pro-neuropeptide Y processing: coexpression and in vitro kinetic investigations.
Proneuropeptide Y (ProNPY) undergoes cleavage at a single dibasic site Lys38-Arg39 resulting in the formation of 1-39 amino acid… 
Highly Cited
1995
Highly Cited
1995
Processing Specificity and Biosynthesis of the Drosophila melanogaster Convertases dfurin1, dfurin1-CRR, dfurin1-X, and dfurin2 (*)
Pro-protein and pro-hormone convertases are subtilisin/kexin-like enzymes implicated in the activation of numerous precursors by… 
Highly Cited
1993
Highly Cited
1993
PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE.
Proteins that transit the constitutive pathway of secretion frequently require proteolytic processing after a pair of basic amino… 
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