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PC-3 cell line

Known as: PC-3 
An adenocarcinoma cell line established in 1979 from a bone metastasis from a 62 year old Caucasian male patient with stage IV prostate carcinoma.
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Characterization of choline uptake in prostate cancer cells following bicalutamide and docetaxel treatment
PurposeCholine derivatives labelled with positron emitters are successfully used for PET imaging of prostate cancer patients… 
Highly Cited
2009
Highly Cited
2009
Oleanane Triterpenoid CDDO‐Me inhibits growth and induces apoptosis in prostate cancer cells by independently targeting pro‐survival Akt and mTOR
Synthetic triterpenoids are potent anticancer agents, but their therapeutic efficacy or mechanism of action for prostate cancer… 
Highly Cited
2008
Highly Cited
2008
Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho.
Thromboxane A(2) (TxA(2)) is a prostanoid formed by thromboxane synthase using the cyclooxygenase product prostaglandin H(2) as… 
Highly Cited
2007
Highly Cited
2007
P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models
P276-00, a flavone that inhibits cyclin-dependent kinases, has been identified by us recently as a novel antineoplastic agent. In… 
Highly Cited
2004
Highly Cited
2004
RRR-α-tocopheryl succinate inhibits human prostate cancer cell invasiveness
RRR-α-tocopheryl succinate (α-vitamin E succinate, VES), one of the vitamin E derivatives, can effectively inhibit the… 
Highly Cited
2003
Highly Cited
2003
Increasing intracellular ceramide: an approach that enhances the cytotoxic response in prostate cancer cells.
Highly Cited
2001
Highly Cited
2001
Voltage‐gated K+ channel activity in human prostate cancer cell lines of markedly different metastatic potential: Distinguishing characteristics of PC‐3 and LNCaP cells
Although ion channels are known to contribute to a variety of basic cellular behaviors involved in the metastatic cascade, their… 
Highly Cited
1998
Highly Cited
1998
Angiogenesis in two human prostate cancer cell lines with differing metastatic potential when growing as solid tumors in nude mice.
Highly Cited
1996
Highly Cited
1996
Bombesin specifically induces intracellular calcium mobilization via gastrin-releasing peptide receptors in human prostate cancer cells.
Bombesin and gastrin-releasing peptide (GRP) are potent neuropeptides expressed by prostate cancer neuroendocrine cells and are… 
Highly Cited
1991
Highly Cited
1991
Involvement of urokinase and its receptor in the invasiveness of human prostatic carcinoma cell lines.
We have investigated the role of urokinase (UK) and its cell-surface receptor in determining the invasiveness of prostate cancer… 
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