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MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
MicroRNAs (miRNAs) are a class of naturally occurring small non-coding RNAs that target protein-coding mRNAs at the post-transcriptional level. Our previous studies suggest that mir-21 functions as
Lipoxygenase metabolism: roles in tumor progression and survival
TLDR
The molecular mechanisms regulated by LOX metabolism in some of the major cancers are focused on, including the effects of LOXs on tumor cell proliferation, their roles in cell cycle control and cell death induction, effects on angiogenesis, migration and the immune response, as well as the signal transduction pathways involved in these processes.
Cyclooxygenases, prostanoids, and tumor progression
TLDR
Aberrant expression and functions of several prostanoid synthetic enzymes in cancer will be discussed and the possible regulation of tumor progression by prostaglandins and their receptors will also be discussed.
Human pregnane X receptor and resistance to chemotherapy in prostate cancer.
TLDR
The data here suggest that hPXR may play an important role in prostate cancer resistance to chemotherapeutics.
G‐protein‐coupled receptor for short‐chain fatty acids suppresses colon cancer
TLDR
The results suggest that GPR43 functions as a tumor suppressor by mediating SCFA‐induced cell proliferation inhibition and apoptotic cell death in colon cancer.
Short-chain fatty acids induced autophagy serves as an adaptive strategy for retarding mitochondria-mediated apoptotic cell death
TLDR
It is demonstrated that propionate-triggered autophagy serves as an adaptive strategy for retarding mitochondria-mediated apoptotic cell death, whereas application of an autophagic inhibitor (Chloroquine) is expected to enhance the therapeutic efficacy of SCFAs in inducing colon tumor cell apoptosis.
Thromboxane A(2) regulation of endothelial cell migration, angiogenesis, and tumor metastasis.
TLDR
Development of lung metastasis in C57Bl/6J mice intravenously injected with Lewis lung carcinoma or B16a cells was significantly inhibited by thromboxane synthase inhibitors, CI or furegrelate sodium.
Regulation of drug resistance by human pregnane X receptor in breast cancer
Drug resistance is a significant barrier to an effective treatment of breast cancer. Human pregnane X receptor (hPXR), an orphan nuclear receptor known for its activation by many important clinical
Thromboxane A2 Regulation of Endothelial Cell Migration, Angiogenesis, and Tumor Metastasis☆
TLDR
Development of lung metastasis in C57Bl/6J mice intravenously injected with Lewis lung carcinoma or B16a cells was significantly inhibited by thromboxane synthase inhibitors, CI or furegrelate sodium.
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