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MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
MicroRNAs (miRNAs) are a class of naturally occurring small non-coding RNAs that target protein-coding mRNAs at the post-transcriptional level. Our previous studies suggest that mir-21 functions as… Expand
Lipoxygenase metabolism: roles in tumor progression and survival
- G. Pidgeon, J. Lysaght, +4 authors K. Honn
- Chemistry, Medicine
- Cancer and Metastasis Reviews
- 18 October 2007
The metabolism of arachidonic acid through lipoxygenase pathways leads to the generation of various biologically active eicosanoids. The expression of these enzymes vary throughout the progression of… Expand
Cyclooxygenases, prostanoids, and tumor progression
In response to various growth factors, hormones or cytokines, arachidonic acid can be mobilized from phospholipids pools and converted to bioactive eicosanoids through cyclooxygenase (COX),… Expand
Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.
- Yakun Chen, Y. Tang, Changxiong Guo, Jiuhui Wang, Debasish Boral, D. Nie
- Biology, Medicine
- Biochemical pharmacology
- 15 April 2012
Chemotherapy is one of the three most common treatment modalities for cancer. However, its efficacy is limited by multidrug resistant cancer cells. Drug metabolizing enzymes (DMEs) and efflux… Expand
Human pregnane X receptor and resistance to chemotherapy in prostate cancer.
Resistance to chemotherapy is a significant barrier to the effective management of prostate cancer. Human pregnane X receptor (hPXR), an orphan nuclear receptor known for its activation by many… Expand
G‐protein‐coupled receptor for short‐chain fatty acids suppresses colon cancer
- Yong Tang, Yakun Chen, Hongmei Jiang, G. T. Robbins, D. Nie
- Biology, Medicine
- International journal of cancer
- 15 February 2011
GPR43 is a G‐protein‐coupled receptor for short‐chain fatty acids (SCFAs). Expression of GPR43 is detected in hematopoietic tissues and the large intestine. SCFAs are derived from bacterial… Expand
Thromboxane A2 Regulation of Endothelial Cell Migration, Angiogenesis, and Tumor Metastasis☆
Prostaglandin endoperoxide H synthases and their arachidonate products have been implicated in modulating angiogenesis during tumor growth and chronic inflammation. Here we report the involvement of… Expand
Differential expression of thromboxane synthase in prostate carcinoma: role in tumor cell motility.
Arachidonic acid metabolism through cyclooxygenase, lipoxygenase, or P-450 epoxygenase pathways can generate a variety of eicosanoids. Thromboxane synthase (TxS) metabolizes the cyclooxygenase… Expand
Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho.
Thromboxane A(2) (TxA(2)) is a prostanoid formed by thromboxane synthase using the cyclooxygenase product prostaglandin H(2) as the substrate. Previously, increased expression of thromboxane synthase… Expand
Regulation of drug resistance by human pregnane X receptor in breast cancer
Drug resistance is a significant barrier to an effective treatment of breast cancer. Human pregnane X receptor (hPXR), an orphan nuclear receptor known for its activation by many important clinical… Expand