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Comprehensive Characterization of Cancer Driver Genes and Mutations
TLDR
This study reports a PanCancer and PanSoftware analysis spanning 9,423 tumor exomes (comprising all 33 of The Cancer Genome Atlas projects) and using 26 computational tools to catalog driver genes and mutations, identifying 299 driver genes with implications regarding their anatomical sites and cancer/cell types. Expand
The Molecular Taxonomy of Primary Prostate Cancer
TLDR
A comprehensive molecular analysis of 333 primary prostate carcinomas revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1). Expand
Oncogenic Signaling Pathways in The Cancer Genome Atlas
TLDR
This work charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity. Expand
Pathogenic Germline Variants in 10,389 Adult Cancers
TLDR
The largest investigation of predisposition variants in cancer to date finds 853 pathogenic or likely pathogenic variants in 8% of 10,389 cases from 33 cancer types, informing future guidelines of variant classification and germline genetic testing in cancer. Expand
Focal adhesion kinase (pp125FAK) expression, activation and association with paxillin and p50CSK in human metastatic prostate carcinoma
TLDR
Results show that an increase in FAK mRNA and protein, as well as pp125FAK activation and association with signalling proteins, correlates with progression and invasion in human PCa tissues and cells. Expand
Capacitation Is Associated with Tyrosine Phosphorylation and Tyrosine Kinase-Like Activity of Pig Sperm Proteins1
TLDR
Indirect immunolocalization showed that the phosphotyrosine residues redistribute to the acrosome during capacitation, which is an appropriate location for a protein involved in the acquisition of fertility. Expand
Bombesin specifically induces intracellular calcium mobilization via gastrin-releasing peptide receptors in human prostate cancer cells.
TLDR
The data indicate that bombesin is a potent inducer of signal transduction via GRP-R receptors in androgen-insensitive PC-3 and DU-145 prostate cancer cells, and suggests that theBombesin/GRP family of neuropeptides may play a regulatory role in the biology of androgens-independent prostate cancer. Expand
Inhibition of mammalian target of rapamycin as a therapeutic strategy in the management of bladder cancer
TLDR
This is the first study showing that RAD001 could be exploited as a potential therapeutic strategy in bladder cancer, and mTOR inhibition by RAD001 demonstrated remarkable antitumor activity both in vitro and in vivo. Expand
Transforming growth factor beta down-regulates Src family protein tyrosine kinase signaling pathways.
TLDR
It is suggested, for the first time, that TGF beta induces down-regulation of Src family kinases, leading to disruption of the SHC-growth factor receptor-bound protein 2 complex, which may play a crucial role in the negative regulation of Ras. Expand
Links between Fer tyrosine kinase expression levels and prostate cell proliferation
TLDR
Fer expression is associated with prostate cell proliferation and enhanced in prostate cancer, and was also expressed in the human prostate carcinoma cell lines DU145 and LNCaP. Expand
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