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PAWR wt Allele

Known as: PAR4, PRKC, Apoptosis, WT1, Regulator wt Allele, par-4 
Human PAWR wild-type allele is located in the vicinity of 12q21.2 and is approximately 99 kb in length. This allele, which encodes the PRKC apoptosis… 
National Institutes of Health

Related topics

Related topics

9 relations
12q21Ceramide Signaling Pathway PIDHomo sapiensPAWR protein, human

Broader (2)

PAWR genePAWR protein

Papers overview

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Highly Cited
2013
Highly Cited
2013
Platelet protease-activated receptor (PAR)4, but not PAR1, associated with neutral sphingomyelinase responsible for thrombin-stimulated ceramide-NF-κB signaling in human platelets
Thrombin activates platelets mainly through protease-activated receptor (PAR)1 and PAR4. However, downstream platelet signaling… 
Highly Cited
2007
Highly Cited
2007
PAR1, but Not PAR4, Activates Human Platelets through a Gi/o/Phosphoinositide-3 Kinase Signaling Axis
Thrombin-mediated activation of platelets is critical for hemostasis, but the signaling pathways responsible for this process are… 
Highly Cited
2006
Highly Cited
2006
Comparison of the effects of PAR1 antagonists, PAR4 antagonists, and their combinations on thrombin-induced human platelet activation.
Highly Cited
2005
Highly Cited
2005
Molecular mechanism and functional implications of thrombin-mediated tyrosine phosphorylation of PKCdelta in platelets.
Thrombin has been known to cause tyrosine phosphorylation of protein kinase C delta (PKCdelta) in platelets, but the molecular… 
Highly Cited
2002
Highly Cited
2002
Role of the PAR4 Thrombin Receptor in Stabilizing Platelet-platelet Aggregates as Revealed by a Patient with Hermansky-Pudlak Syndrome
Summary Individuals with Hermansky-Pudlak Syndrome (HPS) lack platelet dense granules and have no ADP-autocrine response. Despite… 
Review
2002
Review
2002
Protease activated receptor 2 and the cardiovascular system
Protease activated receptors (PARs) represent a novel class of seven transmembrane domain G-protein coupled receptors activated… 
Highly Cited
2001
Highly Cited
2001
Protease‐Activated Receptor (PAR) 1 but Not PAR2 or PAR4 Mediates Endothelium‐Dependent Relaxation to Thrombin and Trypsin in Human Pulmonary Arteries
&NA; Endothelial protease‐activated receptors (PARs) may be important sensors of vascular inflammation and injury. Activation of… 
Highly Cited
2000
Highly Cited
2000
Protease-activated Receptors 1 and 4 Are Shut Off with Distinct Kinetics after Activation by Thrombin*
Protease-activated receptors 1 and 4 (PAR1 and PAR4) mediate thrombin signaling in human platelets. Whether these receptors are… 
Highly Cited
2000
Highly Cited
2000
Structure-Function Analysis of Protease-activated Receptor 4 Tethered Ligand Peptides
Thrombin activates protease-activated receptors (PARs) by specific cleavage of their amino-terminal exodomains to unmask a… 
Review
1999
Review
1999
Protease-Activated Receptors and Platelet Function
Introduction Platelet activation is critical for normal hemostasis, and platelet-dependent arterial thrombosis underlies most… 
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