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PARK7 wt Allele

Known as: DJ1, Parkinson Disease (Autosomal Recessive, Early Oonset) 7 Gene, CTA-215D11.1 
Human PARK7 wild-type allele is located in the vicinity of 1p36.23 and is approximately 31 kb in length. This allele, which encodes protein DJ-1, is… 
National Institutes of Health

Related topics

Related topics

3 relations
ApoptosisNegative Regulation of Apoptosis

Broader (1)

PARK7 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Overexpression of DJ-1 protects against C2-ceramide-induced neuronal death through activation of the PI3K/AKT pathway and inhibition of autophagy
2014
2014
Immunostaining of Oxidized DJ-1 in Human and Mouse Brains
Supplemental digital content is available in the text. 
2014
2014
Genetic susceptibility model of Parkinson's disease resulting from exposure of DJ-1 deficient mice to MPTP: evaluation of neuroprotection by Ubisol-Q10.
INTRODUCTION Parkinson's disease arises from a combination of environmental and genetic risk factors. At present neither the… 
2013
2013
High-expression of DJ-1 and Loss of PTEN Associated with Tumor Metastasis and Correlated with Poor Prognosis of Gastric Carcinoma
Background and aims: DJ-1 and PTEN have been shown to involve in multiple cell processes and play an important role in cancer… 
2013
2013
Oxygen–Glucose‐Deprived Rat Primary Neural Cells Exhibit DJ‐1 Translocation into Healthy Mitochondria: A Potent Stroke Therapeutic Target
DJ‐1 is a key redox‐reactive neuroprotective protein implicated in regulation of oxidative stress after stroke. However, the… 
2011
2011
The Role of DJ-1 in the Pathogenesis of Endometriosis
Background Endometriosis is an estrogen-dependent disease causing pelvic pain and infertility in 10% of reproductive-aged women… 
2010
2010
DJ‐1 forms complexes with mutant SOD1 and ameliorates its toxicity
J. Neurochem. (2010) 113, 860–870. 
2009
2009
Oxidative Neurodegeneration Is Prevented by UCP0045037, an Allosteric Modulator for the Reduced Form of DJ-1, a Wild-Type of Familial Parkinson’s Disease-Linked PARK7
Although a loss-of-function mutation has been identified in familial Parkinson’s disease PARK7, the wild-type of DJ-1 is known to… 
Highly Cited
2007
Highly Cited
2007
Increased vulnerability of nigrostriatal terminals in DJ-1-deficient mice is mediated by the dopamine transporter
Highly Cited
2004
Highly Cited
2004
PET neuroimaging and mutations in the DJ-1 gene
Summary.Mutations in the DJ-1 gene lead to autosomal recessive early-onset parkinsonism. We performed F-DOPA and FDG PET… 
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