PARK7 gene

Known as: DJ1, Parkinsonism associated deglycase, ONCOGENE DJ1 
This gene plays a role in the modulation of apoptotic signaling.
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Parkinson’s disease is a pervasive, ageing-related neurodegenerative disease the cardinal motor symptoms of which reflect the… (More)
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Highly Cited
2009
Highly Cited
2009
In cancer, DJ-1/PARK7 acts as an oncogene that drives Akt-mediated cell survival. Although amplification of DJ-1 has been… (More)
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Highly Cited
2006
Highly Cited
2006
DJ-1 has recently been shown to be responsible for onset of familial Parkinson's disease (PD), PARK7. DJ-1 has been shown to play… (More)
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Highly Cited
2005
Highly Cited
2005
Mutations of the DJ-1 (PARK7) gene are linked to familial Parkinson's disease. We used gene targeting to generate DJ-1-deficient… (More)
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Highly Cited
2005
Highly Cited
2005
The manifestations of Parkinson's disease are caused by reduced dopaminergic innervation of the striatum. Loss-of-function… (More)
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Highly Cited
2004
Highly Cited
2004
Two mutations in the DJ-1 gene on chromosome1p36 have been identified recently to cause early-onset, autosomal recessive… (More)
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Highly Cited
2004
Highly Cited
2004
Deletion and point (L166P) mutations of DJ-1 have recently been shown to be responsible for the onset of familial Parkinson's… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Mutations in the Parkin gene (PARK2) are the most commonly identified cause of recessively inherited early-onset… (More)
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Highly Cited
2003
Highly Cited
2003
Four chromosomal loci (PARK2, PARK6, PARK7, and PARK9) associated with autosomal recessive, early onset parkinsonism are known… (More)
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Highly Cited
2001
Highly Cited
2001
Although the role of genetic factors in the origin of Parkinson disease has long been disputed, several genes involved in… (More)
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