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PALB2 gene

Known as: FANCN, Fanconi anemia, complementation group N, FLJ21816 
This gene may play a role in the repair of DNA damage that is resolved by recombination.
National Institutes of Health

Related topics

Related topics

7 relations
DNA RepairFANCONI ANEMIA, COMPLEMENTATION GROUP NFanconi AnemiaPancreatic carcinoma

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Increased Identification of Candidates for High-Risk Breast Cancer Screening Through Expanded Genetic Testing.
2012
2012
MDC1 and RNF8 function in a pathway that directs BRCA1-dependent localization of PALB2 required for homologous recombination
Summary The PALB2 protein is associated with breast cancer susceptibility and Fanconi anemia. Notably, PALB2 is also required for… 
2011
2011
Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression
PALB2 interacts with BRCA1 and BRCA2 in supercomplexes involved in DNA repair via homologous recombination. Heterozygous germline… 
2011
2011
Germline PALB2 mutation analysis in breast–pancreas cancer families
Background Germline mutations in the PALB2 gene have been implicated in both breast cancer and pancreatic cancer susceptibility… 
2010
2010
Evaluation of the contribution of the three breast cancer susceptibility genes CHEK2, STK11, and PALB2 in non-BRCA1/2 French Canadian families with high risk of breast cancer.
Inactivating mutations of the CHEK2 and STK11 genes are responsible for Li-Fraumeni and Peutz-Jeghers syndrome, respectively… 
Highly Cited
2009
Highly Cited
2009
MRG15 Is a Novel PALB2-interacting Factor Involved in Homologous Recombination*
PALB2 is an integral component of the BRCA complex important for recombinational DNA repair. However, exactly how this activity… 
Review
2009
Review
2009
FANCM-FAAP24 and FANCJ: FA proteins that metabolize DNA.
2009
2009
PALB 2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA 1 and BRCA 2
BRCA1 and BRCA2 are prominently associated with inherited breast and ovarian cancer. The encoded proteins function in DNA damage… 
2008
2008
A major switch for the Fanconi anemia DNA damage–response pathway
  • Weidong Wang
  • Nature Structural &Molecular Biology
  • 2008
  • Corpus ID: 26607334
The Fanconi anemia pathway is part of the DNA-damage network including breast cancer–susceptibility proteins BRCA1 and BRCA2… 
2007
2007
Fanconi anemia and breast cancer susceptibility
Two new studies show that the Fanconi anemia complementation group N results from biallelic mutations in PALB2, which encodes a… 
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