PALB2 gene

Known as: FANCN, Fanconi anemia, complementation group N, FLJ21816 
This gene may play a role in the repair of DNA damage that is resolved by recombination.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Inherited loss-of-function mutations in BRCA1 and BRCA2 and other tumor suppressor genes predispose to ovarian carcinomas, but… (More)
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Review
2010
Review
2010
Partner and localizer of BRCA2 (PALB2) was originally identified as a BRCA2-interacting protein that is crucial for key BRCA2… (More)
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Highly Cited
2009
Highly Cited
2009
Through complete sequencing of the protein-coding genes in a patient with familial pancreatic cancer, we identified a germline… (More)
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Highly Cited
2009
Highly Cited
2009
BRCA1 and BRCA2 are often mutated in familial breast and ovarian cancer. Both tumor suppressors play key roles in the DNA-damage… (More)
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Highly Cited
2009
Highly Cited
2009
Mutations in breast cancer susceptibility gene 1 and 2 (BRCA1 and BRCA2) predispose individuals to breast and ovarian cancer… (More)
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Highly Cited
2007
Highly Cited
2007
PALB2 interacts with BRCA2, and biallelic mutations in PALB2 (also known as FANCN), similar to biallelic BRCA2 mutations, cause… (More)
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Highly Cited
2007
Highly Cited
2007
BRCA1, BRCA2 and other known susceptibility genes account for less than half of the detectable hereditary predisposition to… (More)
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Highly Cited
2007
Highly Cited
2007
PALB2 was recently identified as a nuclear binding partner of BRCA2. Biallelic BRCA2 mutations cause Fanconi anemia subtype FA-D1… (More)
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Highly Cited
2007
Highly Cited
2007
The Fanconi anemia and BRCA networks are considered interconnected, as BRCA2 gene defects have been discovered in individuals… (More)
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Highly Cited
2007
Highly Cited
2007
Inherited breast cancer is associated with germline mutations in ten different genes in pathways critical to genomic integrity… (More)
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