Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins
- Weidong Wang
- BiologyNature reviews genetics
- 1 October 2007
Now that the gene that is defective in the thirteenth and last assigned FA complementation group (FANCI) has been identified, what is known about FA proteins and their interactive network, and what remains to be discovered are discussed.
Rapid and Phosphoinositol-Dependent Binding of the SWI/SNF-like BAF Complex to Chromatin after T Lymphocyte Receptor Signaling
- K. Zhao, Weidong Wang, G. Crabtree
- Biology, ChemistryCell
- 25 November 1998
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2
- B. Xia, J. Dorsman, J. Winter
- BiologyNature Genetics
- 1 February 2007
PALB2-deficient cells showed hypersensitivity to cross-linking agents and lacked chromatin-bound BRCA2; these defects were corrected upon ectopic expression of PALB2 or by spontaneous reversion.
A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M
- A. R. Meetei, A. Medhurst, Weidong Wang
- BiologyNature Genetics
- 21 August 2005
FAAP250 or FANCM has sequence similarity to known DNA-repair proteins, including archaeal Hef, yeast MPH1 and human ERCC4 or XPF and may act as an engine that translocates the Fanconi anemia core complex along DNA.
BRCA1 Is Associated with a Human SWI/SNF-Related Complex Linking Chromatin Remodeling to Breast Cancer
- D. Bochar, Lai Wang, R. Shiekhattar
- BiologyCell
- 21 July 2000
A novel ubiquitin ligase is deficient in Fanconi anemia
- A. R. Meetei, J. Winter, Weidong Wang
- Biology, MedicineNature Genetics
- 1 October 2003
The data suggest that PHF9 has a crucial role in the Fanconi anemia pathway as the likely catalytic subunit required for monoubiquitination of FANCD2.
The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies
- Yutong Xue, R. Gibbons, Weidong Wang
- BiologyProceedings of the National Academy of Sciences…
- 2 September 2003
Results suggest that ATRX functions in conjunction with Daxx in a novel chromatin-remodeling complex that does not randomize DNA phasing of the mononucleosomes, suggesting that it may remodel chromatin differently.
Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.
- Alberto Ciccia, Chen Ling, S. West
- BiologyMolecules and Cells
- 9 February 2007
A Multiprotein Nuclear Complex Connects Fanconi Anemia and Bloom Syndrome
- A. R. Meetei, S. Sechi, Weidong Wang
- BiologyMolecular and Cellular Biology
- 15 May 2003
This study provides the first biochemical characterization of a multiprotein FA complex and suggests a connection between the BLM and FA pathways of genomic maintenance and the findings that FA proteins are part of a DNA-unwinding complex imply thatFA proteins may participate in DNA repair.
PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes.
- Zhijiang Yan, Kairong Cui, Weidong Wang
- BiologyGenes & Development
- 15 July 2005
In vivo evidence is provided that PBAF and BAF regulate expression of distinct genes, and a novel subunit, BAF200, is suggested to play a key role in PBAf function.
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