P2X receptor
National Institutes of Health
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Background/Aims: ATP-gated P2X4 purinergic receptors (P2X4Rs) are cation channels with important roles in diverse cell types. To…
Background: NF449 is a selective P2X1 receptor antagonist. Results: Chimeric/mutant P2X1/4 receptors and molecular docking…
The occupancy of the orthosteric ligand binding sites of P2X receptor (P2XR) channels causes the rapid opening of a small cation…
The transition from the closed to open state greatly alters the intra- and inter-subunit interactions of the P2X receptor (P2XR…
Using a guinea pig heart synaptosomal preparation, we previously observed that norepinephrine (NE) exocytosis was attenuated by a…